ADAMTS2 Antibody
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中文名稱：ADAMTS2兔多克隆抗體
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貨號：CSB-PA576816
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規(guī)格：￥1090
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圖片：
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Western blot analysis of HepG2 K562 Hela Colo using ADAMTS-2 antibody.. Secondary antibody was diluted at 1:20000
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：ADAMTS2
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別名：A disintegrin and metalloproteinase with thrombospondin motifs 2 antibody; A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 2 antibody; ADAM metallopeptidase with thrombospondin type 1 motif 2 antibody; ADAM TS 2 antibody; ADAM TS2 antibody; ADAM-TS 2 antibody; ADAM-TS2 antibody; ADAMTS 3 antibody; ADAMTS-2 antibody; ADAMTS2 antibody; ATS2_HUMAN antibody; EC 3.4.24.14 antibody; EDS VIIB antibody; EDS VIIC antibody; hPCPNI antibody; NPI antibody; PC I NP antibody; PC I-NP antibody; PCINP antibody; PCPNI antibody; pNPI antibody; Procollagen I N proteinase antibody; Procollagen I N-proteinase antibody; Procollagen I/II amino propeptide processing enzyme antibody; Procollagen I/II amino propeptide-processing enzyme antibody; Procollagen N endopeptidase antibody; Procollagen N-endopeptidase antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Synthesized peptide derived from the C-terminal region of Human ADAMTS-2. at AA rangle: 1140-1211
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：WB, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 ELISA 1:10000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. Cleaves lysyl oxidase LOX at a site downstream of its propeptide cleavage site to produce a short LOX form with reduced collagen-binding activity.
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基因功能參考文獻(xiàn)：
- We identified three novel homozygous loss-of-function mutations (c.2927_2928delCT, p.(Pro976Argfs*42); c.669_670dupG, p.(Pro224Argfs*24); and c.2751-2A>T) and one compound heterozygous mutation (c.2T>C, p.? and c.884_887delTGAA, p.(Met295Thrfs26*)) in ADAMTS2 in five patients from four unrelated families PMID: 26765342
- Data indicate that ADAMTS2 and 3 cleave the amino-propeptide of fibrillar collagens and regulate blood vessels homeostasis and lymphangiogenesis. Also, ADAMTS2 deficiency leads to the dermatosparactic type of Ehlers-Danlos syndrome. [review] PMID: 25863161
- IL-1a is a strong positive regulator of ADAMTS-2 and ADAMTS-3 expression. PMID: 26232334
- ADAMTS2 was significantly overexpressed in Fibrous dysplasia (FD) tissues, but rarely expressed in normal bone tissues, suggesting that ADAMTS2 could be a potential biomarker for FD PMID: 25674217
- Pathway inhibition studies revealed that ADAMTS-2 upregulation by IL-6 was mediated by JNK pathway. PMID: 24752352
- Data show that ADAMTS-2 is able to reduce proliferation of endothelial cells, and to induce their retraction and detachment from the substrate resulting in apoptosis. PMID: 20574651
- Determination of the processing, activity and cleavage specificity of the bovine ADAMTS2 protein. PMID: 16046392
- when conditioned media of TSP2-transfectants were added to cultures of bovine pulmonary microvascular endothelial cells (BPMEC), the BPMEC proliferation was significantly inhibited; suggesting that human TSP2 is a potential inhibitor of angiogenesis PMID: 11788898
- Although exons 3-5 or 14-16 encode protein domains that have not been recognized as crucial for ADAMTS-2 activity, the aminoprocollagen processing was strongly impaired, providing evidence for the requirement of these domains for proper enzyme function PMID: 15373769
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相關(guān)疾病：Ehlers-Danlos syndrome 7C (EDS7C)
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亞細(xì)胞定位：Secreted, extracellular space, extracellular matrix.
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組織特異性：Expressed at high level in skin, bone, tendon and aorta and at low levels in thymus and brain.
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數(shù)據(jù)庫鏈接：
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