ACOX1 Antibody

Name: ACOX1 Antibody
Brand: CUSABIO
SKU: CSB-PA617998HA01HU

文獻引用 (2) 說明書

中文名稱：

ACOX1兔多克隆抗體
貨號：

CSB-PA617998HA01HU
規(guī)格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA617998HA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA617998HA01HU at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA617998HA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產(chǎn)品詳情
產(chǎn)品評價
引用文獻
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) ACOX1 Polyclonal antibody
Uniprot No.：

Q15067
基因名：

ACOX1
別名：

ACOX antibody; ACOX1 antibody; ACOX1_HUMAN antibody; Acyl CoA oxidase 1 palmitoyl antibody; Acyl CoA oxidase straight chain antibody; AOX antibody; EC 1.3.3.6 antibody; PALMCOX antibody; Palmitoyl CoA oxidase antibody; Palmitoyl-CoA oxidase antibody; Peroxisomal acyl coenzyme A oxidase 1 antibody; Peroxisomal acyl-coenzyme A oxidase 1 antibody; Peroxisomal fatty acyl CoA oxidase antibody; SCOX antibody; Straight chain acyl CoA oxidase antibody; Straight-chain acyl-CoA oxidase antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Peroxisomal acyl-coenzyme A oxidase 1 protein (113-273AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產(chǎn)品，ACOX1 Antibody (CSB-PA617998HA01HU)，的標記方式是Non-conjugated。對于ACOX1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA617998HB01HU	ACOX1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA617998HC01HU	ACOX1 Antibody, FITC conjugated
Biotin	CSB-PA617998HD01HU	ACOX1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

引用文獻

Unveiling the crucial role of peroxisomal acyl-CoA metabolism in muscle atrophy: Insights from genetic models and therapeutic interventions S Jiang, HS Kim, JH Ryu, YS Lee, DI Kim, EJ Jin,Nano Today,2024
Deficiency of peroxisomal NUDT7 stimulates de novo lipogenesis in hepatocytes J Song,iScience,2022

產(chǎn)品評價

靶點詳情

功能：

Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. First enzyme of the fatty acid beta-oxidation pathway.; Shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length.; Is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs. Is twice as active as isoform 1 against 16-hydroxy-palmitoyl-CoA and is 25% more active against 1,16-hexadecanodioyl-CoA.
基因功能參考文獻：
1. Because patients with AOx deficiency suffer from more severe symptoms than those with X-ALD, accumulation of VLC-PUFA and/or reduction of DHA may be associated with the severity of peroxisomal diseases. PMID: 24418004
2. ACOX1 and GNPAT silencing up-regulated ceramide galactosyltransferase (UGT8) mRNA expression, and down-regulated UDP-glucoseceramide glucosyltransferase (UGCG). PMID: 23933200
3. Data show that human ACOX1b isoform is more effective than the ACOX1a isoform in reversing the Acox1 null phenotype in the mouse. PMID: 20195242
4. Mutational spectrum of peroxisomal acyl-coenzyme A oxidase deficiency. PMID: 17458872
5. report on two new patients with ACOX1 deficiency and mutational analyses PMID: 18536048
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相關(guān)疾病：

Adrenoleukodystrophy, pseudoneonatal (Pseudo-NALD)
亞細胞定位：

Peroxisome.
蛋白家族：

Acyl-CoA oxidase family
組織特異性：

Widely expressed with highest levels of isoform 1 and isoform 2 detected in testis. Isoform 1 is expressed at higher levels than isoform 2 in liver and kidney while isoform 2 levels are higher in brain, lung, muscle, white adipose tissue and testis. Level
數(shù)據(jù)庫鏈接：

HGNC: 119

OMIM: 264470

KEGG: hsa:51

STRING: 9606.ENSP00000293217

UniGene: Hs.464137

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