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中文名稱：大鼠前白蛋白(PA)酶聯免疫試劑盒
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貨號：CSB-E13251r
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規格：96T/48T
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價格：￥3900/￥2500
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其他：
產品詳情
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產品描述：大鼠前白蛋白(PA)酶聯免疫試劑盒（CSB-E13251r）為競爭法ELISA試劑盒，定量檢測血清、血漿、組織培養上清液、組織勻漿樣本中的PA含量。試劑盒檢測范圍為375 ng/mL-6000 ng/mL，在肝損傷模型、營養干預研究及相關疾病機制探索中具有重要科研價值；可用于評估肝細胞功能、監測培養體系中蛋白質分泌動態，或分析組織樣本病理生理變化；滿足基礎研究中對PA定量分析的需求。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
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別名：Ttr ELISA Kit; Tt ELISA Kit; Transthyretin ELISA Kit; Prealbumin ELISA Kit; TBPA ELISA Kit
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縮寫：PA
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Uniprot No.：
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種屬：Rattus norvegicus (Rat)
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樣本類型：serum, plasma, cell culture supernates, tissue homogenates
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檢測范圍：375 ng/mL-6000 ng/mL
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靈敏度：375 ng/mL
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反應時間：1-5h
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樣本體積：50-100ul
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檢測波長：450 nm
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研究領域：Cardiovascular
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測定原理：quantitative
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測定方法：Competitive
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精密度：
Intra-assay Precision (Precision within an assay): CV%<8% Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV%<10% Three samples of known concentration were tested in twenty assays to assess. -
線性度：
To assess the linearity of the assay, samples were spiked with high concentrations of rat PA in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay. Sample Serum(n=4) 1:200 Average % 95 Range % 91-99 1:400 Average % 103 Range % 99-107 1:800 Average % 98 Range % 95-103 1:1600 Average % 93 Range % 87-97 -
回收率：
The recovery of rat PA spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section. Sample Type Average % Recovery Range Serum (n=5) 99 95-103 EDTA plasma (n=4) 89 82-97 -
標準曲線：
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed. 
ng/ml OD1 OD2 Average 6000 0.152 0.163 0.158 3000 0.288 0.300 0.294 1500 0.561 0.568 0.565 750 0.903 0.925 0.914 375 1.477 1.434 1.456 0 2.662 2.591 2.627 -
數據處理：
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貨期：3-5 working days
引用文獻
- Changes in semen characteristics and sex hormones of rats treated with iron oxide nanoparticles, silver nanoparticles and their mixture AI Younus,Gsc biological pharmaceutical sciences,2020
- Quantitative Analysis of the Proteome and the Succinylome in the Thyroid Tissue of High-Fat Diet-Induced Hypothyroxinemia in Rats B Hu,International Journal of Endocrinology,2020
產品評價
相關產品
靶點詳情
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功能：Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.
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基因功能參考文獻：
- Data suggest that the mutated transthyretin (TTR) seems to have potential as biomarker for early detection of hepatocellular carcinoma (HCC). PMID: 28876464
- Serum transthyretin level dramatically decreased in animals displaying decompression sickness symptoms. PMID: 27068327
- We conclude that stress upregulates TTR expression in choroid plexus. PMID: 22371232
- Decreased trophoblast expression of retinol transport proteins suggest that nitrofen may interfere with the fetal retinol transport resulting in reduced pulmonary RBP and TTR levels and causing pulmonary hypoplasia in CDH. PMID: 22015466
- Data demonstrate that, in vitro and in vivo, transthyretin is up-regulated by progesterone, and suggest that this response is mediated through a progesterone receptor-mediated mechanism. PMID: 20535645
- Structural basis of negative cooperativity in transthyretin PMID: 11995997
- Complex of rat transthyretin with tetraiodothyroacetic acid refined at 2.1 and 1.8 A resolution PMID: 11995998
- Comparison of binding interactions of dibromoflavonoids with transthyretin PMID: 11995999
- Amyloid formation in rat transthyretin: effect of oxidative stress PMID: 12135814
- data show the LR1 gene is up-regulated following short interval successive partial hepatectomy; it may play an important role in liver regeneration PMID: 12508371
- Data suggest that monomeric transthyretin may represent an ischemia-specific CSF marker to indicate the sequential changes according to ischemic insults of the brain. PMID: 15469881
- Our study provides genetic, behavioural and molecular evidence that TTR is involved in the maintenance of normal cognitive processes during aging by acting on the retinoid signalling pathway. PMID: 17512093
- Ttr mRNA expression in dorsal root ganglia and cauda equina. PMID: 18406527
- Sex hormones may increase TTR synthesis by the liver, and therefore, may contribute to amyloid deposition. PMID: 18568387
- Results suggest that transthyretin is up-regulated by estradiol via a pathway involving estrogen receptors alpha and beta. PMID: 19130215
- The expression of transthyretin in brain of a transgenic mouse model of Alzheimer's disease is asymmetric and affected by age and sex. PMID: 19167467
- rat and murine TTR have a lower intrinsic beta-aggregation propensity and a similar native beta-structure stability compared with human TTR. PMID: 19602727
- Transthyretin is expressed in the pineal gland >30-fold higher than the median expression level in other tissues, at levels similar to those in the choroid plexus. PMID: 19103603
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亞細胞定位：Secreted.
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蛋白家族：Transthyretin family
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組織特異性：Detected in serum and cerebrospinal fluid (at protein level). Highly expressed in the choroid plexus. Detected at lower levels in the liver.
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