Plg是一種廣泛存在于人體內的血漿蛋白，在多種疾病的發生和發展中可能發揮著重要的作用。最近的研究表明，Plg參與了腫瘤生長、血管生成、轉移和免疫逃逸等多個方面的調節，并在心血管疾病、肺部疾病和肝臟疾病中的作用備受關注。對Plg結構和功能的研究也取得了重要進展，這將有助于更深入地了解Plg的生物學特性，為新藥物的開發和治療策略的制定提供更可靠的理論基礎。

Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.; Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo.

1. Angiostatin overexpression was associated with attenuated renal disease progression in a model of chronic kidney injury, likely because of its anti-inflammatory actions. PMID: 18971211
2. Expression of angiostatin in the ischemic tissues after ischemia-reperfusion in diabetes mellitus + cerebral ischemia group increased significantly. PMID: 19932587
3. plasmin has a role as an intracellular protease PMID: 12928439
4. Plasminogen-induced IL-1beta, TNF-alpha, and iNOS mRNA expression in primary cultured rat microglia and BV2 murine microglial cells. PMID: 14651966
5. Plg gene expression is up-regulated by nerve growth factor PMID: 17663741
6. Plasmin activates epithelial Na+ channels by cleaving the gamma subunit PMID: 18981180

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Secreted.

Peptidase S1 family, Plasminogen subfamily

KEGG: rno:85253

STRING: 10116.ENSRNOP00000023370

UniGene: Rn.20178