1. Compound 49b treatment inhibited these retinal changes. In REC cultured in hypoxia, levels of IGFBP-3 were reduced, which were significantly increased by Compound 49b. PMID: 27439004
2. Study indicated that IGFBP-3 shRNA might rehabilitate erectile function via decreased concentrations of serum LDL lipoprotein and triglyceride, increased cavernosal smooth muscle and improvement in NO-cGMP signaling in diabetic rats. PMID: 25879169
3. IGFBP-3 shRNA may rehabilitate erectile function via increases of concentrations of serum testosterone and cavernous cyclic guanosine monophosphate in streptozotocin-induced diabetic rats PMID: 25582342
4. IGFBP-3 has novel protective effects on retinal and systemic vasculature and may be a therapeutic candidate for ocular complications such as diabetic retinopathy. PMID: 22792172
5. obesity induces specific changes in the expression profile of the adipose tissue depot surrounding the pancreas, leading to a decrease in IGFBP3 secretion PMID: 22067319
6. The results support the suggestion that inactivation of Mxi1 has a positive effect on cell proliferation by down-regulating IGFBP-3. PMID: 22008548
7. Paraquat-treated rats showed enhanced gene expression of growth factors such as platelet-derived growth factor-A and insulin-like growth factor-1 at 21 days and transforming growth factor-beta 1 at 14 days. PMID: 20498031
8. Data suggest that the inhibitory effect of chronic arthritis on skeletal muscle is higher in fast glycolytic than in slow oxidative muscle and that IGF-I administration attenuates this effect and decreases atrogin-1 and IGFBP-3 gene expression. PMID: 20519361
9. Downregulation of IGFBP-3 gene expression may cause pulmonary hypoplasia in the nitrofen-induced CDH model by interfering with retinoid signaling pathway. PMID: 19844724
10. IGFBP-3 and BAX interaction activates germ cell apoptosis via the mitochondria-dependent pathway. PMID: 19887447
11. IGFBP-3 and -5 proteins may have potential modulatory roles in type I fiber-dominated muscles, aging, and regrowth from atrophy. PMID: 12397024
12. role of glucocorticoids in the insulin-like growth factor binding protein (IGFBP)-3 response to endotoxin PMID: 12485840
13. Expressed in cardiac muscle cells. Serum withdrqwal-induced increase in apoptosis of cardiac muscle cells associated with IGFBP-3. PMID: 12508914
14. data indicate that acute inflammation inhibits serum concentrations of IGFBP-3 by decreasing its synthesis in the liver, rather than increasing its proteolysis PMID: 12581876
15. Aminoguanidine inhibition of inducible nitric oxide synthase blocked the inhibitory effect of LPS on both IGFBP-3 serum levels and its hepatic mRNA levels. PMID: 13129855
16. IGFBP-3 could play proapoptotic action at the myocardial level and suggest a novel role for this protein in cardiovascular dysfunction. PMID: 15055478
17. IGF-I uses different and only partially overlapping intracellular signaling pathways for regulation of IGFBP-3 and -5 with opposing biological functions might be important for modulation of IGF bioactivity in cellular microenvironment. PMID: 15845624
18. cross-talk between the IGFBP-3-dependent STAT-1 signaling and the TGF-beta-dependent ERK pathway that regulates mesenchymal chondroprogenitor cell proliferation PMID: 15956343
19. In utero dibutyl phthalate leads to IGFBP3 expression in rat testis in fetal and postnatal development. PMID: 16037377
20. retinoic acid modulates the secreted IGFBP-2 and -3 during O(2) exposure and inhibits the increase in collagen that occurs during lung injury PMID: 16055936
21. Liver cirrhosis is accompanied by an altered spatial expression of IGFBP-3 PMID: 16098781
22. Intracerebroventricular infusion of IGFBP-3 significantly impaired insulin action at the liver (45% increase in hepatic glucose production, P < 0.01). PMID: 17003344

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KEGG: rno:24484

STRING: 10116.ENSRNOP00000011678

UniGene: Rn.26369