Rat Collagen alpha-1(I) chain (COL1A1) ELISA kit
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中文名稱：大鼠I型膠原α1鏈 (COL1A1)酶聯(lián)免疫試劑盒
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貨號：CSB-E12732r
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規(guī)格：96T/48T
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價格：￥3800/￥2500
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其他：
產(chǎn)品詳情
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產(chǎn)品描述：大鼠I型膠原α1鏈 (COL1A1)酶聯(lián)免疫試劑盒（CSB-E12732r）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的COL1A1含量。COL1A1 是重要靶點。它編碼Ⅰ型膠原的α1鏈，在維持組織穩(wěn)態(tài)中起關(guān)鍵作用。研究發(fā)現(xiàn)其表達(dá)異常與纖維化疾病、腫瘤進(jìn)展密切相關(guān)，機(jī)制可能涉及信號通路激活、微環(huán)境重塑等，是潛在的疾病診斷和治療靶點。試劑盒檢測范圍為0.156 ng/mL-10 ng/mL，適用于科研場景中探究纖維化疾病模型（如肝纖維化、肺纖維化）的分子機(jī)制、評估藥物干預(yù)對膠原代謝的影響，或用于組織工程研究中細(xì)胞外基質(zhì)動態(tài)變化的監(jiān)測，為相關(guān)領(lǐng)域的體外實驗提供高靈敏度的檢測工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
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別名：COL1A1Collagen alpha-1(I) chain ELISA kit; Alpha-1 type I collagen ELISA kit; Fragment ELISA kit
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縮寫：
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Uniprot No.：
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種屬：Rattus norvegicus (Rat)
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樣本類型：serum, plasma, tissue homogenates
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檢測范圍：0.156 ng/mL-10 ng/mL
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靈敏度：0.039 ng/mL
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反應(yīng)時間：1-5h
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樣本體積：50-100ul
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檢測波長：450 nm
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研究領(lǐng)域：Signal Transduction
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測定原理：quantitative
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測定方法：Sandwich
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數(shù)據(jù)處理：
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貨期：3-5 working days
引用文獻(xiàn)
- iTRAQ-based proteomic analysis of combination therapy with taurine, epigallocatechin gallate, and genistein on carbon tetrachloride-induced liver fibrosis in rats. Cao W.et al,Toxicol Lett.,2015
- Lentiviral Vector-Mediated FoxO1 Overexpression Inhibits Extracellular Matrix Protein Secretion Under High Glucose Conditions in Mesangial Cells. Guo F.et al,J Cell Biochem.,2016
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：Type I collagen is a member of group I collagen (fibrillar forming collagen).
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亞細(xì)胞定位：Secreted, extracellular space, extracellular matrix.
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蛋白家族：Fibrillar collagen family
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組織特異性：Forms the fibrils of tendon, ligaments and bones. In bones the fibrils are mineralized with calcium hydroxyapatite.
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數(shù)據(jù)庫鏈接：
UniGene: Ocu.3445
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