APOA5是一種與三酰甘油代謝和心血管疾病風(fēng)險密切相關(guān)的蛋白。最新的研究表明，APOA5可能還具有調(diào)節(jié)肝細(xì)胞脂代謝和炎癥反應(yīng)的作用。一項發(fā)表在Journal of Lipid Research上的研究發(fā)現(xiàn)，APOA5通過調(diào)節(jié)脂代謝酶基因的表達(dá)，影響肝臟脂質(zhì)代謝和三酰甘油的水平。此外，一些研究還發(fā)現(xiàn)，APOA5與胰島素抵抗、非酒精性脂肪肝等疾病有關(guān)。

Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and an inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. Binds heparin.

1. Our data support the hypothesis that apoA5 promotes hepatic TG storage and therefore contributes to the pathogenesis of non-alcoholic fatty liver disease PMID: 25938357
2. Demonstrate that apoA-V is secreted into bile, introducing a potential route of delivery of hepatic apoA-V to the gut lumen. PMID: 26505974
3. The increase in apolipoprotein A mRNA induced by rosiglitazone is not directly mediated by peroxisome proliferator-activated receptor gamma.[apolipoprotein av] PMID: 16570166
4. apoA-V inefficiently traffics within the secretory pathway, that its intracellular itinerary can be regulated by changes in cellular TG accumulation, and that apoA-V synthesis can modulate VLDL TG mobilization and secretion. PMID: 21115968
5. decreased apolipoprotein A5 is implicated in insulin resistance-related hypertriglyceridemia in obesity PMID: 20047745
6. ApoA-V ability to enhance insulin secretion in beta-cells and provide evidence of an internalization pathway involving the midkine as partner. PMID: 19910685
7. the hypotriglyceridemic gene APOA5 is regulated by thyroid hormone PMID: 15941710
8. The absence of significant changes in Apoa5 gene expression during chronic fructose-induced triglyceride elevation excludes its major role in mechanisms compensating severe hypertriglyceridemia PMID: 16238453
9. data suggest that the C terminus of apoA-V is essential for lipid droplet association in transfected hepatoma cells and lipoprotein association in conditioned medium while the signal peptide is required for extracellular trafficking of this protein. PMID: 18450648

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Secreted. Early endosome. Late endosome. Golgi apparatus, trans-Golgi network.

Apolipoprotein A1/A4/E family

Liver.

KEGG: rno:140638

STRING: 10116.ENSRNOP00000024918

UniGene: Rn.48763