Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.; Lactotransferrin is a major iron-binding and multifunctional protein found in exocrine fluids such as breast milk and mucosal secretions. Has antimicrobial activity. Antimicrobial properties may include bacteriostasis, which is related to its ability to sequester free iron and thus inhibit microbial growth, as well as direct bactericidal properties leading to the release of lipopolysaccharides from the bacterial outer membrane. May have anabolic, differentiating and anti-apoptotic effects on osteoblasts and may also inhibit osteoclastogenesis, possibly playing a role in the regulation of bone growth. May interfere with the lipopolysaccharide (LPS)-stimulated TLR4 signaling.; The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity. Shows a preferential cleavage at -Arg-Ser-Arg-Arg-|- and -Arg-Arg-Ser-Arg-|-, and of Z-Phe-Arg-|-aminomethylcoumarin sites.

1. this paper shows that recombinant lactoferrin peptide LF-6 produced with intein technology has both antibacterial and immunomodulatory activity in mice PMID: 27487204
2. We propose that lactoferrin functions in the immune defense of the small intestinal mucosa by targeting the population of T cells in the lamina propria PMID: 20607309
3. Involvement of HSP27 and lactoferrin in porcine endometrium and neutrophils activity. PMID: 20541878
4. Growth performance of animal pups is enhanced by directly feeding the genetically engineered milk containing enriched pLF protein in transgenic mice. PMID: 17489602

Secreted. Cytoplasmic granule.

Transferrin family

KEGG: ssc:397649

STRING: 9823.ENSSSCP00000026769

UniGene: Ssc.11136