Mouse Vascular cell adhesion molecule 1,VCAM-1 ELISA kit

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中文名稱：

小鼠血管內皮細胞粘附分子1(VCAM-1/CD106)酶聯免疫試劑盒
貨號：

CSB-E04754m
規格：

96T/48T
價格：

￥3800/￥2500
其他：

CUSABIO Wins 2024 Bioz Rapid Star? Award in the ELISA category

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小鼠血管內皮細胞粘附分子1(VCAM-1/CD106)酶聯免疫試劑盒（CSB-E04754m）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織培養上清液、組織勻漿樣本中的VCAM1含量。VCAM1（血管細胞粘附分子1）是一種細胞表面糖蛋白，屬于免疫球蛋白超家族。它主要在活化的內皮細胞表面表達，通過與白細胞表面的特定分子結合，調節炎癥反應和白細胞遷移。VCAM1在免疫反應和炎癥過程中發揮重要作用，其表達增加與多種免疫性疾病和癌癥的進展密切相關。研究顯示，VCAM1通過調節小膠質細胞的功能和Aβ的清除，在阿爾茨海默病的發生發展中扮演關鍵角色。試劑盒檢測范圍為39.062 pg/mL-2500 pg/mL，靈敏度為29.649 pg/mL。適用于體外研究血管內皮細胞活化狀態、炎癥反應機制、藥物干預效果評估等科研領域，為心血管疾病、免疫調控及腫瘤微環境等領域的機制研究提供可靠工具。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
別名：

Vcam1; Vcam-1; Vascular cell adhesion protein 1; V-CAM 1; VCAM-1; CD antigen CD106
縮寫：

VCAM1
Uniprot No.：

P29533
種屬：

Mus musculus (Mouse)
樣本類型：

serum, plasma, cell culture supernates, tissue homogenates
檢測范圍：

39.062 pg/mL-2500 pg/mL
靈敏度：

29.649 pg/mL
反應時間：

1-5h
樣本體積：

50-100ul
檢測波長：

450 nm
研究領域：

Cardiovascular
測定原理：

quantitative
測定方法：

Sandwich
精密度：

Intra-assay Precision (Precision within an assay): CV%<8%

Three samples of known concentration were tested twenty times on one plate to assess.

Inter-assay Precision (Precision between assays): CV%<10%

Three samples of known concentration were tested in twenty assays to assess.
線性度：

To assess the linearity of the assay, samples were spiked with high concentrations of mouse VCAM-1/CD106 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
標準曲線：

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
數據處理：

ELISA操作視頻及標曲繪制軟件下載
貨期：

3-5 working days

引用文獻

Lead-induced actin polymerization aggravates neutrophil extracellular trap formation and contributes to vascular inflammation Q Nong, Y Wu, S Liu, Y Tang, J Wu, H Huang,Ecotoxicology and Environmental Safety,2025
The synergistic effect of Ficus carica nanoparticles and Praziquantel on mice infected by Schistosoma mansoni cercariae NA El-Attar, MR El-Sawi, EA El-Shabasy,Scientific Reports,2024
Estimation the Effect of Ficus carica Active components' Nanoparticles on Mice Infected by Schistosomal cercariae and treated with praziquantel NA El,/,2024
Wenyang Huazhuo Tongluo formula alleviates pulmonary vascular injury and downregulates HIF-1α in bleomycin-induced systemic sclerosis mouse model K Li,BMC complementary medicine and therapies,2022
A Novel STAT3-Mediated GATA6 Pathway Contributes to tert-Butylhydroquinone- (tBHQ-) Protected TNFα-Activated Vascular Cell Adhesion Molecule 1 (VCAM-1) in Vascular Endothelium L Zhou,Oxidative Medicine and Cellular Longevity,2020
MicroRNA-29a-3p Reduces TNFa-Induced Endothelial Dysfunction by Targeting Tumor Necrosis Factor Receptor X Deng,Mol Ther Nucleic Acids,2020
Plasma endothelial cells-derived extracellular vesicles promote wound healing in diabetes through YAP and the PI3K/Akt/mTOR pathway F Wei,Aging (Albany NY),2020
MicroRNA-29a-3p reduces TNFα-induced endothelial dysfunction by targeting tumor necrosis factor receptor 1 Deng X, et al,Molecular Therapy-Nucleic Acids,2019

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最新研究進展：

VCAM1是一種黏附分子，參與細胞黏附和遷移過程，已被證實與許多疾病的發生和發展有關，如動脈粥樣硬化和腫瘤的形成。最新的研究表明，VCAM1可能參與心血管疾病的發生和發展，并被認為是一種治療心血管疾病的潛在靶點。此外，VCAM1的水平還可以作為某些疾病的診斷和預后標志物。
功能：

Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
亞細胞定位：

[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Cell membrane; Lipid-anchor, GPI-anchor.
組織特異性：

Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue. Expressed in the bone marrow.
數據庫鏈接：

STRING: 10090.ENSMUSP00000029574

UniGene: Mm.440909

Mouse Vascular cell adhesion molecule 1,VCAM-1 ELISA kit

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