1. Data suggest that big-h3 protein (BIGH3) acts as a tumor suppressor in the retina. PMID: 28099942
2. findings demonstrate a novel role of lithium in the inhibition of colon cancer metastasis by blocking TGFBIp expression, and thereby TGFBIp-induced lymphangiogenesis, in primary tumors. PMID: 26857144
3. TGF-beta-induced matricellular protein-null lungs displayed diminished elastic recoil and gas exchange efficiency PMID: 26878215
4. Vicenin-2 and scolymoside could be a potential therapeutic agent for treatment of various severe vascular inflammatory diseases via inhibition of the TGFBIp signaling pathway. PMID: 26084452
5. the data suggest a model by which cytokine-induced Myt3 suppression leads to Tgfbi de-repression and subsequently to impaired islet-cell migration, revealing a novel role for Myt3 in regulating islet-cell migration. PMID: 26177052
6. Studies reveal that growth hormone (GH)increases TGFBI expression in a mouse and rat models of diabetic nephropathy (DN) which correlate with clinical results, and suggest that this mechanism can explain the podocytes depletion in DN. PMID: 25740786
7. Tgfbi deficiency is associated with the degradation of cartilage matrix PMID: 25450762
8. The results support a novel inflammatory pathway for diabetic retinopathy. This pathway is initiated by TGFbeta released from macrophages, which promotes synthesis and release of BIGH3 protein by REC and REC apoptosis. PMID: 25378215
9. TGFBI is a potential risk gene for human diabetes. PMID: 24728038
10. High blood TGFBIp levels were observed in cecal ligation and puncture (CLP)-induced septic mice. The absence of the TGFBIp gene in mice attenuated CLP-induced sepsis. PMID: 24506343
11. Collectively, our findings indicate that betaig-h3 promotes the fibrogenic influence of TGFbeta signaling, neutralizing the prochondrogenic influence of the hypoxic-inducible factor 1 activated by the microenvironment of limb mesenchymal aggregates. PMID: 22924741
12. the observed effect of TGFBI on bone mass and bone size was largely caused by the effect of TGFBI on periosteal bone formation PMID: 22644324
13. betaig-h3 bears alphavbeta3 integrin-interacting motifs that mediate endothelial cell adhesion and migration and angiogenesis PMID: 12704192
14. The spatiotemporal distribution of Beta-ig during various stages of murine development was examined and its ability to support adhesion of various cell types assessed PMID: 12963107
15. During pregnancy, high levels of betaig-h3 mRNA were detected in the uterus on Day 4 of gestation, when the trophoblastic invasion of the implanted blastocysts was very active. PMID: 14967934
16. Recombinant beta ig-h3 and its FAS1 domain significantly inhibit in vitro osteoblast differentiation as evaluated by matrix mineralization/bone nodule formation. PMID: 15780949
17. analysis of mouse fasciclin-containing genes (betaigH3, periostin, stabilin-1, and stabilin-2) expression patterns during valvuloseptal morphogenesis PMID: 15907457
18. keratoepithelin may help to build up a bridge between collagen VI and yet unidentified muscle receptor PMID: 18249103
19. Betaig-h3 may play a critical role as a regulator of chondrogenic differentiation in endochondral ossification. PMID: 18779658
20. Blocking of betaig-h3 expression in E12.5 embryos with antisense oligodeoxynucleotides resulted in cleft of the secondary palate PMID: 19415673

顯示更多

收起更多

KEGG: mmu:21810

STRING: 10090.ENSMUSP00000037719

UniGene: Mm.14455