Mouse Secretoglobin family 3A member 2(SCGB3A2) ELISA kit
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中文名稱:小鼠分泌球蛋白家族3A成員2(SCGB3A2)酶聯(lián)免疫試劑盒
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貨號(hào):CSB-EL020819MO
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規(guī)格:96T/48T
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價(jià)格:¥3600/¥2500
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其他:
產(chǎn)品詳情
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產(chǎn)品描述:小鼠分泌球蛋白家族3A成員2(SCGB3A2)酶聯(lián)免疫試劑盒(CSB-EL020819MO)為雙抗夾心法ELISA試劑盒,定量檢測(cè)血清、血漿、組織勻漿、細(xì)胞裂解物樣本中的SCGB3A2含量。SCGB3A2(分泌性杯狀細(xì)胞相關(guān)蛋白 3A2)是重要的肺上皮細(xì)胞分泌蛋白。它常作為肺臟相關(guān)疾病的潛在靶點(diǎn)。研究機(jī)制方面,主要聚焦其在肺組織穩(wěn)態(tài)維持、炎癥反應(yīng)調(diào)控等過程中的作用,探索通過干預(yù)它來治療如肺纖維化等疾病。試劑盒檢測(cè)范圍為9.4 pg/mL-600 pg/mL,適用于小鼠模型中肺纖維化、哮喘等呼吸道疾病的分子機(jī)制探索、藥物干預(yù)效果評(píng)估及SCGB3A2表達(dá)調(diào)控研究,支持科研人員高效開展體外實(shí)驗(yàn)。本產(chǎn)品僅限用于科學(xué)研究領(lǐng)域,不適用于其他用途。本品僅用于科研,不用于臨床診斷,產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
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別名:Scgb3a2 ELISA Kit; Pnsp1 ELISA Kit; Ugrp1 ELISA Kit; Secretoglobin family 3A member 2 ELISA Kit; Pneumo secretory protein 1 ELISA Kit; PnSP-1 ELISA Kit; Uteroglobin-related protein 1 ELISA Kit
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縮寫:SCGB3A2
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Uniprot No.:
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種屬:Mus musculus (Mouse)
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樣本類型:serum, plasma, tissue homogenates, cell lysates
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檢測(cè)范圍:9.4 pg/mL-600 pg/mL
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靈敏度:2.35 pg/mL
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反應(yīng)時(shí)間:1-5h
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樣本體積:50-100ul
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檢測(cè)波長:450 nm
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研究領(lǐng)域:Epigenetics and Nuclear Signaling
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測(cè)定原理:quantitative
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測(cè)定方法:Sandwich
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精密度:
Intra-assay Precision (Precision within an assay): CV%<8% Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV%<10% Three samples of known concentration were tested in twenty assays to assess. -
線性度:
To assess the linearity of the assay, samples were spiked with high concentrations of mouse SCGB3A2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay. Sample Serum(n=4) 1:1 Average % 87 Range % 82-91 1:2 Average % 94 Range % 89-98 1:4 Average % 107 Range % 103-110 1:8 Average % 110 Range % 104-114 -
回收率:
The recovery of mouse SCGB3A2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section. Sample Type Average % Recovery Range Serum (n=5) 95 91-99 EDTA plasma (n=4) 103 98-108 -
標(biāo)準(zhǔn)曲線:
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed. pg/ml OD1 OD2 Average Corrected 600 2.511 2.468 2.490 2.318 300 1.672 1.699 1.686 1.514 150 1.015 0.989 1.002 0.830 75 0.594 0.586 0.590 0.418 37.5 0.403 0.412 0.408 0.236 18.75 0.292 0.289 0.291 0.119 9.4 0.218 0.207 0.213 0.041 0 0.171 0.173 0.172 -
數(shù)據(jù)處理:
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貨期:3-5 working days
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能:Secreted cytokine-like protein. Binds to the scavenger receptor MARCO. Can also bind to pathogens including the Gram-positive bacterium L.monocytogenes, the Gram-negative bacterium P.aeruginosa, and yeast. Strongly inhibits phospholipase A2 (PLA2G1B) activity. Seems to have anti-inflammatory effects in respiratory epithelium. Also has anti-fibrotic activity in lung. May play a role in fetal lung development and maturation. Promotes branching morphogenesis during early stages of lung development. In the pituitary, may inhibit production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH).
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基因功能參考文獻(xiàn):
- These results demonstrate that SCGB3A2 has an anti-inflammatory activity in the HDM-induced allergic airway inflammation model, in which SCGB3A2 may modulate the CCR4-CCL17 pathway. PMID: 27820933
- The pulmonary fibrosis in the Scgb3a2-null mice was more severe than the wild-type controls, thus establishing that SCGB3A2 has anti-fibrotic activity in vivo. PMID: 26559674
- SCGB3A2 is an anti-fibrotic agent, and suggest a possible therapeutic use of recombinant SCGB3A2 in the treatment of pulmonary fibrosis. PMID: 26178733
- The results indicate that the loss of SCGB3A2 function was influenced by a modifier gene(s) in mixed genetic background and suggest that SCGB3A2 has anti-inflammatory property. PMID: 25242865
- SCGB3A2 regulates FSH/LH production in the anterior pituitary lobe. PMID: 24514953
- Secretoglobin 3A2 suppresses bleomycin-induced pulmonary fibrosis by transforming growth factor beta signaling down-regulation PMID: 21478551
- Results demonstrate that SCGB3A2 is a useful marker for diagnosis of pulmonary tumors both in mice and humans. PMID: 20466451
- UGRP1 does not play a major role in the development of bronchial asthma in our Caucasian population. PMID: 12915772
- results demonstrate that interleukin-10 induces uteroglobin related protein 1(UGRP1) gene expression in lung epithelial cells through transcription factor T/EBP/NKX2.1-dependent pathway PMID: 15485815
- UGRP1 is downregulated in inflamed airways, such as allergic asthmatics. PMID: 15531759
- To assess a potential role for SCGB3A2 during early lung development, wild-type and Nkx2-1-null fetal lungs of early developmental stages were subjected to ex vivo organ culture in the presence of SCGB3A2. PMID: 18535256
- C/EBPalpha and C/EBPdelta have a role in the synergistic interaction with NKX2-1 in mouse Scgb3a2 gene transcription and lung development PMID: 18632661
- SCGB3A2 gene may contribute to Graves' disease susceptibility. PMID: 19126779
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亞細(xì)胞定位:Secreted.
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蛋白家族:Secretoglobin family, UGRP subfamily
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組織特異性:Highly expressed in lung where it localizes to epithelial cells of the trachea, bronchus and bronchioles (at protein level). Expressed in club/Clara cells of the bronchioles. Also detected in the anterior and posterior lobes of the pituitary gland where i
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