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中文名稱：小鼠巨噬細胞炎性蛋白1β(MIP-1β/CCL4)酶聯免疫試劑盒
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貨號：CSB-E04665m
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規格：96T/48T
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價格：￥3200/￥2500
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其他：
產品詳情
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產品描述：小鼠巨噬細胞炎性蛋白1β(MIP-1β/CCL4)酶聯免疫試劑盒（CSB-E04665m）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的CCL4含量。CCL4，即C-C趨化因子配體4，是一種由免疫細胞和腫瘤細胞分泌的細胞因子，主要在正常組織中不表達或弱表達，但在多種惡性腫瘤組織中異常高表達。CCL4與CCR5受體結合后，可招募免疫細胞，破壞腫瘤微環境穩定性，參與致癌并促進腫瘤發展。其研究機制涉及調節腫瘤微環境中的免疫細胞組成和功能，對腫瘤的發生發展及免疫逃逸有重要影響。試劑盒檢測范圍為12.5 pg/mL-800 pg/mL，本試劑盒采用特異性抗體對目標蛋白進行捕獲與檢測，操作流程標準化，適用于科研領域中對小鼠模型炎癥相關機制的研究，例如在感染性疾病模型、自身免疫疾病模型或免疫調節實驗中定量分析MIP - 1β/CCL4的表達動態，亦可應用于藥物開發或免疫干預研究中評估該趨化因子的水平變化。實驗支持多種生物樣本類型檢測，為探索炎癥微環境及免疫調控網絡提供可靠工具。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
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別名：Ccl4 ELISA Kit; Mip1b ELISA Kit; Scya4 ELISA Kit; C-C motif chemokine 4 ELISA Kit; Immune activation protein 2 ELISA Kit; ACT-2 ELISA Kit; ACT2 ELISA Kit; Macrophage inflammatory protein 1-beta ELISA Kit; MIP-1-beta ELISA Kit; Protein H400 ELISA Kit; SIS-gamma ELISA Kit; Small-inducible cytokine A4 ELISA Kit
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縮寫：
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Uniprot No.：
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種屬：Mus musculus (Mouse)
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樣本類型：serum, plasma, tissue homogenates
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檢測范圍：12.5 pg/mL-800 pg/mL
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靈敏度：3.12 pg/mL
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反應時間：1-5h
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樣本體積：50-100ul
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檢測波長：450 nm
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研究領域：Immunology
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測定原理：quantitative
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測定方法：Sandwich
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精密度：
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線性度：
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回收率：
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標準曲線：
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數據處理：
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貨期：3-5 working days
引用文獻
- Hepatocyte-specific deficiency of Nrf2 exacerbates carbon tetrachlorideinduced liver fibrosis via aggravated hepatocyte injury and subsequent inflammatory and fibrogenic responses Hang Lyu,Free Radical Biology and Medicine,2020
- HMBOX1 in hepatocytes attenuates LPS/D-GalN-induced liver injury by inhibiting macrophage infiltration and activation HengliZhao.et al,Molecular Immunology,2018
- Autoimmune-prone NOD mice help reveal a new genetic locus for reducing pulmonary disease caused by Mycoplasma pulmonis Wawegama NK.et al,Infect Immun,2017
產品評價
相關產品
靶點詳情
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功能：Monokine with inflammatory and chemokinetic properties.
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基因功能參考文獻：
- CCL4-CCR5 axis can contribute to breast cancer metastasis to bone by mediating the interaction between cancer cells and fibroblasts in bone cavity. PMID: 27177471
- YY1 regulates lung CCL4 transcription in pulmonary tuberculosis. PMID: 26786659
- Ccl4 mRNAs increased within 5 h after injury in mouse cortical slices. PMID: 25895671
- CCL4 and CCL5 expression was higher in livers of infected WSX-1(-/-) mice than infected WT mice, and hepatic CD4 T cells from WSX-1(-/-) mice expressed higher levels of CCR5 than cells from WT mice PMID: 24244314
- CCL4 upregulation was associated with increased Snail expression and downregulation of p53/PTEN in high-grade PIN and prostate cancer PMID: 23878190
- These results suggest that MIP-1beta is a novel key mediator, and the peripheral MIP-1beta-CCR5 axis contributes to neuropathic pain. PMID: 22528550
- results indicate that MIP-1beta is involved in the recruitment of bone marrow-derived monocyte lineage cells PMID: 21912378
- increased responsiveness of murine eosinophils to MIP-1beta is mediated by CCR5 receptor in mice PMID: 12050188
- macrophage inflammatory protein-1beta is a hypoxia-induced neutrophil survival factor. PMID: 15630139
- MIP-1beta is overexpressed, and VE-cadherin is underexpressed in heart transplant allografts compared with isografts PMID: 15897346
- Overproduction of MIP-1beta in chemokine (C-C motif) receptor 5-deficient mice after collagen II-immunization may contribute partially to the occurrence of arthritis PMID: 15967376
- The expression and role CXCL12 and CCL4 and their receptors (CXCR4 and CCR5) in regulating thymocyte migration in conjunction with extracellular matrix during acute T. cruzi infection are investigated. PMID: 16637021
- ATF3 appears to be part of a control mechanism that limits the amount of CCL4 released by macrophages, preventing excessive inflammation. PMID: 16982098
- Antibody neutralization of CCL4 abrogates the ability of T-cells from IL-4-treated NOD mice to transfer protection against type 1 diabetes. PMID: 17327452
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亞細胞定位：Secreted.
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蛋白家族：Intercrine beta (chemokine CC) family
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數據庫鏈接：
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