1. Gastrin induces nuclear export and proteasome degradation of menin in duodenal glial cells. PMID: 28859856
2. PTHLH is a gastrin-regulated growth factor that might contribute to gastric epithelial cell homeostasis. PMID: 28408643
3. Renal-selective silencing of Gast by the renal subcapsular injection of Gast siRNA in BALB/c mice decreases renal dopamine production and increases blood pressure. PMID: 27780818
4. Gastrin is expressed in insulin secreting cells of adult diabetic mice. PMID: 27864307
5. increased circulating concentrations of progastrin provide a physiological advantage against systemic hypoxia in mice PMID: 25394662
6. Ihh signaling mediates gastrin-induced proliferation of epithelial cells in stomachs of adult mice. PMID: 24859162
7. Data indicate that epithelial Gli2 expression was sufficient to stimulate Il-1beta expression, repress Gast gene expression and increase proliferation, leading to antral hyperplasia. PMID: 23110168
8. gastrins play an important direct role, unrelated to their ability to stimulate acid secretion, in hematopoiesis under conditions of iron deficiency. PMID: 21652729
9. Initiation of antral gastric cancer is associated with progressive epigenetic silencing of TFF1, which can be suppressed by the hormone gastrin. PMID: 21111741
10. Regulation of mouse gastrin gene in vivo. Mechanisms involved in transcriptional control of the gastrin gene. PMID: 21051525
11. RegI and gastrin may synergistically regulate gastric mucosal proliferation during certain pathological settings like wound healing PMID: 19969026
12. To examine the importance of gastrin or its receptors during development in general and for gastric physiology specifically both have been knocked out. PMID: 11713979
13. stimulates the growth of gastric pit cell precursors by inducing its own receptors. PMID: 11804858
14. Endocrine gastrin may have a role in the colonic adenoma carcinoma sequence. Hyper-gastrinaemia may promote proliferation of human colonic adenomas that express CCK-2 receptor isoforms. PMID: 12189558
15. Parietal cells were found to be significantly smaller in the mutant cell preparations, suggesting that gastrin stimulation modulates parietal cell morphology. PMID: 12388185
16. essential physiologic role for gastrin in glucose homeostasis; however, the gastrin gene is not essential for murine islet development or the adaptive islet proliferative response to beta-cell injury. PMID: 14517799
17. gastrin promoter is activated by transforming growth factor-beta/Smad and Wnt signaling pathways PMID: 15292219
18. gastrin expression, possibly contributing to neoplastic progression, is induced by synergistic Wnt and Ras signaling pathway PMID: 16139800
19. The aim of this study was to evaluate changes in the acid-secreting parietal cell in gastrin-deficient (GAS-KO) mice. PMID: 16278279
20. Hypergastrinemia increases regeneration of intestinal epithelia following diverse forms of injury. PMID: 16618411
21. gastrin can induce apoptosis in gastric epithelial cells and contribute to the development of gastric carcinogenesis PMID: 16894354
22. Gastrin concentrations are increased in the plasma and gastric mucosa of Hfe(-/-) mice, and in the sera of humans with HFE-related hemochromatosis. PMID: 17064691
23. Gastrin regulates TFF2 transcription through a GC-rich DNA-binding site and a protein kinase dependent pathway. PMID: 17332476
24. Identification of ezrin as a target of gastrin in immature mouse gastric parietal cells. PMID: 18567601
25. Results suggest that RNAi targeting of gastrin could serve as an effective treatment for pancreatic cancer. PMID: 19465883

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KEGG: mmu:14459

STRING: 10090.ENSMUSP00000017309

UniGene: Mm.4767