FN1（fibronectin-1）是一種大分子的膠原蛋白家族成員，參與許多生理和病理過程，如細(xì)胞外基質(zhì)形成、胚胎發(fā)育、細(xì)胞粘附、細(xì)胞遷移、組織修復(fù)和癌癥進(jìn)展等。最近的研究表明，F(xiàn)N1在許多疾病中發(fā)揮關(guān)鍵作用，如肝纖維化、心臟病、腎病、癌癥和炎癥性疾病等。研究人員正在研究FN1在這些疾病中的作用機(jī)制，并探索潛在的治療方法，以利用其作為潛在治療靶點(diǎn)的潛力。此外，研究還表明，F(xiàn)N1可以作為一種診斷和預(yù)測生物標(biāo)記物，用于腫瘤的早期診斷和治療反應(yīng)的監(jiān)測。

Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts.; Binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.

1. Lack of Fibronectin Extra Domain A Alternative Splicing Exacerbates Endothelial Dysfunction in Diabetes. PMID: 27897258
2. fibronectins from different sources contribute differentially to specific aspects of angiogenesis. PMID: 28667352
3. Factor XIII-A and TG2 regulate resorption, adipogenesis and plasma fibronectin homeostasis in bone and bone marrow. PMID: 28387755
4. we disclosed the role of chemotaxis and apoptosis in the fibrotic microenvironment-enhanced seeding of tumor cells and identified the fibroblast-derived FN1 and SPP1 as the central mediators in these processes PMID: 27329720
5. FN is a fundamental component of the hematopoietic tissue and that the EIIIA exon may play a key role in modulating hematopiesis in conditions of bone marrow stress or diseases. PMID: 27090359
6. PD increased CKIP-1 and Nrf2 levels in the kidney tissues as well as improved the anti-oxidative effect and renal dysfunction of diabetic mice, which eventually reversed the up-regulation of FN and ICAM-1 PMID: 28286065
7. fibronectin has a critical role in tissue morphogenesis and the development of tissue heterogeneities PMID: 27564551
8. The aged stem cell niche in skeletal muscle contains reduced levels of FN, leading to detrimental consequences for the function and maintenance of muscle stem cells (MuSCs). FN is a preferred adhesion substrate for MuSCs and integrin-mediated signaling via focal adhesion kinase and the p38 MAPK pathway is strongly de-regulated in MuSCs from aged mice because of insufficient attachment to the niche. PMID: 27376579
9. analysis of novel functions for two fibronectin isoforms and the mediating receptors in osteoblast differentiation PMID: 28325836
10. scleraxis was required for TGFbeta-induced fibronectin expression: TGFbeta lost its ability to induce fibronectin expression following scleraxis knockdown. PMID: 27324126
11. The results very comprehensively demonstrate distinct signaling pathways that regulate microfilament organization, lamellipodial structures, spreading, and movement of cells plated on galectin-3 as opposed to fibronectin. PMID: 27130204
12. Thus, similarly to growth factor signaling, fibronectin matrix assembly during early development can be both autocrine and paracrine. PMID: 26845241
13. These results suggest that the Rac1 regulation of the FN arrangement is involved in retinoic acid-induced cleft palate. PMID: 26329303
14. Fibrillar cellular fibronectin supports platelet adhesion, activation, aggregation and procoagulant activity via the interplay of a series of receptors i.e. integrins alpha5beta1 and alphaIIbbeta3, the GPIb-V-IX complex, GPVI and Toll-like receptor 4. PMID: 26245230
15. Fn1 synthesized by the neural crest mediated morphogenesis of the aortic arch artery and differentiation of neural crest cells into vascular smooth muscle cells by regulating Notch signaling. PMID: 26552887
16. These findings indicate an indispensable role for Fn in chronic liver fibrosis/cirrhosis. PMID: 26553870
17. Hypercholesterolemic mice deficient in extra domain A of fibronectin exhibit reduced cerebral thrombosis. PMID: 26508731
18. the epithelial interaction between fibronectin and beta1 integrin is important for ameloblast differentiation and enamel formation. PMID: 25830530
19. An (as yet unknown) integrin alpha5-dependent signal extrinsic to the pharyngeal endothelium mediates the formation of the 4th pharyngeal arch arteries through fibronectin. PMID: 26434918
20. TLR4 signaling contributes to EDA(+)-FN-mediated exacerbation of atherosclerosis. PMID: 26427793
21. 5-HT) inhibits Factor XIII-A-mediated plasma fibronectin matrix assembly and crosslinking in osteoblast cultures via direct competition with transamidation PMID: 25460579
22. This study demonstrated that the EIIIA domain of aFn mediates proliferation of OPCs, but not migration. PMID: 25156142
23. The DP-4 peptide activated Fn and enhanced cell adhesion activity PMID: 25092262
24. demonstrate the susceptibility of FN in the extracellular matrix to proteolysis and the resulting loss of cell adhesion due to the decrease of FN activity PMID: 25724944
25. fibronectin secretion has a role in mesothelial cells promotion of early ovarian cancer metastasis PMID: 25202979
26. These data suggest that adhesion to vitronectin allows for the uncoupling of fibronectin fibril formation from downstream signaling events by reducing alpha5beta1 integrin activation and fibronectin fibril extension. PMID: 24509439
27. Notch signaling is required for proper lymphatic valve formation and regulates integrin alpha9 and fibronectin EIIIA expression during valve morphogenesis PMID: 24917500
28. Regional differences in cell proliferation and fibronectin structure were dependent on both soluble fibronectin concentration and fibronectin-collagen type I interactions. PMID: 24116223
29. Data indicate that both fibronectin and VEGF then cooperate to stimulate blood vessel formation. PMID: 23908593
30. Silencing fibronectin expression produced similar effects as miR-378a-5p. PMID: 24060687
31. our data point to a potential role for the fibronectin-alpha5beta1 integrin interaction in promoting vascular remodeling during demyelinating disease PMID: 24056042
32. Fibronectin and integrin alpha5beta1 have critical roles in mouse embryogenesis PMID: 23791818
33. Fibronectin is essential for endogenous cardiac progenitor cell expansion and repair required for stabilization of cardiac function after myocardial infarction. PMID: 23652800
34. Loss of fibronectin negatively affects precardiac mesoderm. PMID: 23715551
35. Extra domain A-containing fibronectin is necessary for the development of nasal tissue fibrotic remodeling process in both murine and human allergic rhinitis. PMID: 23622001
36. cleavage by gingipains directly affects the biological activity of both fibronectin and tenascin-C in a manner that might lead to increased cell detachment and loss during periodontal disease. PMID: 23313574
37. FN and Wnt7a together regulate the homeostatic levels of satellite stem cells and satellite myogenic cells during regenerative myogenesis. PMID: 23290138
38. RhoA activates NFAT by inducing a rise of [Ca(2+)]i in podocytes, which in turn contributes to fibronectin upregulation. PMID: 23389455
39. Fetal fibronectin activates MMP-1, MMP-9, and COX-2 in mesenchymal cells and causes preterm labor in mice. PMID: 23184961
40. Fibronectin stimulates migration through lipid raft dependent NHE-1 activation in mouse embryonic stem cells. PMID: 22683701
41. Data indicate that beta3 integrin is required for Pyk2 cell surface localization and fibronectin accumulation. PMID: 22984613
42. analysis of force induced fibronectin assembly and matrix remodeling in a 3D microtissue model of tissue morphogenesis PMID: 22961409
43. Data indicate that expression of fibronectin (FN) was significantly higher in primary macrophages than in a macrophage-like cell line, RAW264.7, suggesting that abundant FN might suppress the responsiveness in the primary macrophages. PMID: 22809727
44. Dataset suggests a possible role for fibronectin and its proteolytic fragments in venous thrombus resolution and identifies a novel N-terminal-derived 50 kDa fibronectin fragment that: contains the Vegf binding site. PMID: 22640974
45. This work defines fibronectin as a novel antiapoptotic factor for hepatocytes after acute liver injury, but demonstrates that fibronectin is not essential for subsequent hepatocyte proliferation. PMID: 22318920
46. By providing cell adhesive signals that can act with other self-renewal factors to maintain embryonic stem cell pluripotency, fibronectin is a necessary component of the self-renewal signaling pathway in culture. PMID: 22710062
47. Data indicate that peptide-based molecular probes capable of selectively discriminating fibronectin (Fn) fibers under different strain states. PMID: 22529344
48. Cellular fibronectin that contains the alternatively spliced extra domain A (EIIIA)promotes hepatic stellate cell motility but not differentiation into myofibroblasts. PMID: 22202457
49. Data suggest that fibronectin is a critical mediator for TGF-beta-specific production balance of 2 major proteoglycans, aggrecan and versican, during chondrogenesis. PMID: 21822533
50. Bacillus anthracis infection contribute to the formation of thrombi consisting of aggregated bacteria, vWF, shed SDC-1, fibrin, activated platelets and fibronectin. PMID: 22001909

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Secreted, extracellular space, extracellular matrix.

Expressed in the inner limiting membrane and around blood vessels in the retina (at protein level). Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or cross-linked multimeric forms), made by fibroblasts, epithelial and ot

KEGG: mmu:14268

STRING: 10090.ENSMUSP00000054499

UniGene: Mm.193099