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中文名稱：小鼠補體C2(C2)酶聯(lián)免疫試劑盒
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貨號：CSB-EL003658MO
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規(guī)格：96T/48T
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價格：￥3600/￥2500
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其他：
產(chǎn)品詳情
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產(chǎn)品描述：小鼠補體C2(C2)酶聯(lián)免疫試劑盒（CSB-EL003658MO）為競爭法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的C2含量。小鼠補體C2（C2）是參與補體系統(tǒng)經(jīng)典途徑和凝集素途徑的關(guān)鍵蛋白，其功能包括與C4b結(jié)合形成C4bC2復(fù)合體，隨后被激活的C1s或MASP2切割成C2a和C2b，其中C2a與C4b結(jié)合形成C3轉(zhuǎn)化酶，激活C3和C5，從而放大補體級聯(lián)反應(yīng)，介導(dǎo)炎癥和細胞損傷。試劑盒檢測范圍為18.75 ng/mL-300 ng/mL，該產(chǎn)品可廣泛應(yīng)用于基礎(chǔ)免疫學(xué)研究，支持小鼠模型中補體系統(tǒng)功能分析、炎癥相關(guān)疾病機制探索、藥物干預(yù)效果評估等科研場景，尤其適用于通過血清或組織樣本動態(tài)監(jiān)測補體C2在病理生理過程中的表達變化。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
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別名：C2Complement C2 ELISA Kit; EC 3.4.21.43 ELISA Kit; C3/C5 convertase) [Cleaved into: Complement C2b fragment; Complement C2a fragment] ELISA Kit
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縮寫：
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Uniprot No.：
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種屬：Mus musculus (Mouse)
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樣本類型：serum, plasma, tissue homogenates
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檢測范圍：18.75 ng/mL-300 ng/mL
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靈敏度：18.75 ng/mL
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反應(yīng)時間：1-5h
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樣本體積：50-100ul
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檢測波長：450 nm
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研究領(lǐng)域：Immunology
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測定原理：quantitative
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測定方法：Competitive
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數(shù)據(jù)處理：
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貨期：3-5 working days
引用文獻
- Integrative cross‐tissue analysis unveils complement‐immunoglobulin augmentation and dysbiosis‐related fatty acid metabolic remodeling during mammalian aging F Zhang, R Li, Y Liu, J Liang, Y Gong, C Xiao, J Cai,iMeta,2025
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靶點詳情
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功能：Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.
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基因功能參考文獻：
- Data indicate that activation of C5 in experimental cerebral malaria likely occurs via coagulation enzymes of the extrinsic protease pathway. PMID: 22689574
- The more pronounced lack of complement activation in Bf/C2-/- mice leads to uncontrolled infection due to an opsonophagocytic defect PMID: 18672286
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亞細胞定位：Secreted.
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蛋白家族：Peptidase S1 family
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數(shù)據(jù)庫鏈接：
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