Human selenium binding protein 1(SELENBP1) ELISA Kit
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中文名稱：人硒結(jié)合蛋白1 (SELENBP1)酶聯(lián)免疫試劑盒
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貨號：CSB-E13947h
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規(guī)格：96T/48T
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價格：￥3600/￥2500
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其他：
產(chǎn)品詳情
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產(chǎn)品描述：人硒結(jié)合蛋白1 (SELENBP1)酶聯(lián)免疫試劑盒（CSB-E13947h）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的SELENBP1含量。人硒結(jié)合蛋白1（SELENBP1）是一種與硒結(jié)合的蛋白，其在多種癌癥類型中可能發(fā)揮抗癌作用。其表達水平與免疫浸潤和免疫治療密切相關(guān)，研究顯示SELENBP1在結(jié)直腸癌中表達降低，與不良預后相關(guān)，且其表達影響腫瘤免疫浸潤和化療、免疫治療的敏感性。試劑盒檢測范圍為125 pg/mL-8000 pg/mL，該產(chǎn)品適用于體外研究SELENBP1在疾病模型、藥物干預實驗或生理條件下的表達調(diào)控，例如通過分析腫瘤組織勻漿或炎癥動物模型的血清樣本，探究其與氧化應(yīng)激相關(guān)通路的關(guān)聯(lián)性。科研人員可利用定量評估不同處理條件下SELENBP1的動態(tài)變化，為分子機制研究提供可靠數(shù)據(jù)支持。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
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別名：56 kDa selenium binding protein ELISA Kit; 56 kDa selenium-binding protein ELISA Kit; hSBP ELISA Kit; LPSB ELISA Kit; SBP ELISA Kit; SBP1 ELISA Kit; SBP1_HUMAN ELISA Kit; SBP56 ELISA Kit; Selenbp1 ELISA Kit; Selenbp2 ELISA Kit; Selenium Binding Protein 1 ELISA Kit; Selenium binding protein 2 ELISA Kit; Selenium binding protein1 ELISA Kit; Selenium-binding protein 1 ELISA Kit; SELNBP1 ELISA Kit; SP56 ELISA Kit
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縮寫：
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Uniprot No.：
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種屬：Homo sapiens (Human)
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樣本類型：serum, plasma, tissue homogenates
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檢測范圍：125 pg/mL-8000 pg/mL
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靈敏度：31.25 pg/mL
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反應(yīng)時間：1-5h
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樣本體積：50-100ul
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檢測波長：450 nm
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研究領(lǐng)域：Cancer
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測定原理：quantitative
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測定方法：Sandwich
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精密度：
Intra-assay Precision (Precision within an assay): CV%<8% Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV%<10% Three samples of known concentration were tested in twenty assays to assess. -
線性度：
To assess the linearity of the assay, samples were spiked with high concentrations of human SELENBP1 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay. Sample Serum(n=4) 1:1 Average % 84 Range % 80-88 1:2 Average % 97 Range % 91-105 1:4 Average % 97 Range % 92-104 1:8 Average % 93 Range % 86-98 -
回收率：
The recovery of human SELENBP1 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section. Sample Type Average % Recovery Range Serum (n=5) 95 89-98 EDTA plasma (n=4) 94 90-100 -
標準曲線：
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed. 
pg/ml OD1 OD2 Average Corrected 8000 2.520 2.604 2.562 2.367 4000 2.203 2.214 2.209 2.014 2000 1.888 1.899 1.894 1.699 1000 1.445 1.496 1.471 1.276 500 1.005 1.067 1.036 0.841 250 0.673 0.681 0.677 0.482 125 0.378 0.384 0.381 0.186 0 0.194 0.196 0.195 -
數(shù)據(jù)處理：
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貨期：3-5 working days
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靶點詳情
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功能：Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria. Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport.
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基因功能參考文獻：
- High anti-SBP1 is associated with infertile women with premature ovarian failure. PMID: 27965399
- Downregulation of selenium-binding protein 1 is associated with lung squamous cell carcinoma. PMID: 26956891
- cysteine 57 is a critical determinant of SBP1 function and may play a significant role in mitochondrial function. PMID: 26593911
- Data indicate that loss of SBP1 may play an independent contributing role in prostate cancer progression and its levels might be useful in distinguishing indolent from aggressive disease. PMID: 25993660
- elevated transcript expression is widespread throughout the prefrontal cortex in schizophrenia PMID: 26241353
- These results have revealed a novel mechanism that SELENBP1-mediated cancer inhibition is through altering lipid/glucose metabolic signaling pathways. PMID: 25974208
- Decreased selenium-binding protein 1 mRNA expression is associated with renal cell carcinoma. PMID: 25227434
- hSP56 plays an important role in regulating HIF-1alpha, which may be one of mechanisms of hSP56 expression in suppressing the malignant characteristics of prostate cancer cells. PMID: 24874852
- the downregulated SELENBP1 expression was reactivated by inducing differentiation. Therefore, SELENBP1 is a potential pharmacological target for individualized CRC treatment. PMID: 24737289
- Decreased SELENBP1 expression is an early event in lung squamous cell cancer tumorigenesis. PMID: 23977169
- The expression level of SELENBP1 could be an important marker for predicting survival and effectiveness of selenium supplementation in breast cancer. PMID: 23704933
- These results suggest that SBP1 plays a significant role in gastric cancer cell proliferation and modulates its response to anticancer drugs PMID: 23483240
- SP1 is present in reduced levels in several cancer types as compared with normal tissues, and lower levels are associated with poor clinical prognosis. PMID: 20530237
- Glutathione peroxidase (GPx)-1 enzyme activity is inversely correlated with selenium binding protein (SBP)-1 levels in prostate tissue, based on the Gleason score. PMID: 22072582
- The suppression of Selenium-binding protein 1 may be a late event in gastric carcinogenesis. PMID: 20480265
- The 3-year survival rate of gastric cancer patients with high expression of selenium-binding protein 1 was significantly higher than that of patients with low expression PMID: 21497372
- down-regulation of SBP1 may play a key role in the tumorigenic process of human gastric carcinoma PMID: 20354826
- Decreased expression of selenium-binding protein 1 in uterine leiomyoma may indicate a role of the protein in tumorigenesis. PMID: 21143902
- A reduced SELENBP1 expression by immunohistochemistry in liver tissues of patients with hepatocarcinoma (HCC), is reported. PMID: 21338716
- evidence for recurrence of decreased copy-number of the SELENBP1 locus in three unrelated schizophrenia patients' cohorts but not in controls, raising the possibility of functional involvement of these mutations in the etiology of the disease PMID: 20615253
- SELENBP1 expression may be an important predictor of response to chemoprevention or chemosensitization with certain forms of selenium in esophageal tissues. PMID: 20332323
- SBP1 has tumor suppressor functions that are inhibited in colorectal cancer through epigenetic silencing PMID: 19924303
- loss of selenium-binding protein 1 associated with increasing epithelial proliferation indicates selenium-binding protein 1 is involved in tumorigenesis of ovarian and micropapillary serous borderline tumor and low-grade serous carcinoma. PMID: 19896693
- SBP may be involved in the initial sequential events in rapid cell outgrowth, such as determining direction of cell outgrowth and recruitment of actin monomer. PMID: 15108003
- changes of SELENBP1 expression in malignant ovarian cancer are an indicator of aberration of selenium/androgen pathways and may reveal prognostic information of ovarian cancer PMID: 16380993
- Suppression of SELENBP1 is a frequent and late event in colorectal carcinogenesis, and may contribute to the rapid progression of colorectal carcinoma. PMID: 16645984
- Elevated SELENBP1 is a possibly consistent feature in the schizophrenic brain and this could underlie some commonalities of psychosis across the boundaries of diagnoses. PMID: 18163446
- Associated with differentiation of the normal colonic epithelia and may be a positive prognostic factor for survival in stage III colorectal carcinoma PMID: 18435490
- VDU1 was identified as a protein partner of hSP56. PMID: 19118533
- The genetic variation in SELENBP1 may influence risk for the disorder, while this significance did not remain when other inheritance models were considered. PMID: 19596560
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亞細胞定位：Nucleus. Cytoplasm, cytosol. Membrane; Peripheral membrane protein.
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蛋白家族：Selenium-binding protein family
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組織特異性：Widely expressed. Highly expressed in liver, lung, colon, prostate, kidney and pancreas. In brain, present both in neurons and glia (at protein level). Down-regulated in lung adenocarcinoma, colorectal carcinoma and ovarian cancer. Two-fold up-regulated i
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