PIBF1是一種由基因PIBF1編碼的蛋白質，具有重要的免疫調節和抗炎作用。最近的研究表明，PIBF1在某些自身免疫性疾病中發揮了重要作用，如自身免疫性病變、重癥肌無力和系統性紅斑狼瘡等。此外，PIBF1還參與了腫瘤的免疫逃逸和轉移過程。

Plays a role in ciliogenesis.; Pericentriolar protein required to maintain mitotic spindle pole integrity. Required for the centrosomal accumulation of PCM1 and the recruitment of centriolar satellite proteins such as BBS4. Via association with PCM1 may be involved in primary cilia formation. Required for CEP63 centrosomal localization and its interaction with WDR62. Together with CEP63 promotes centriole duplication. Promotes the centrosomal localization of CDK2.; The secreted form is a mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling decidual naturakl killer cells (NK) activity exerts an anti-abortive effect. Increases the production of Th2-type cytokines by signaling via the JAK/STAT pathway. Activates STAT6 and inhibits STAT4 phosphorylation. Signaling via a not identified receptor seems to implicate IL4R and a GPI-anchored protein.

1. We found at high levels of expression of PIBF protein in epithelial ovarian cancer patients. These data demonstrate that tumor cells can secrete PIBF to escape the immune system PMID: 29962287
2. blood and placental tissue level expression of PIBF is concordant and correlates with both progesterone receptor expression status as well as final pregnancy outcome PMID: 27728856
3. this study shows that preterm birth may be predictable at 24-28 gestational week by lower than normal pregnancy PIBF values PMID: 27479613
4. B cells are a significant producer of PIBF1 in human choriodecidua in late gestation. Preterm labor was associated with a lower level of active PIBF1 in late gestation choriodecidua. PMID: 27918564
5. PIBF plays a role in both normal pregnancy and tumor biology. PMID: 20367622
6. PIBF promotes proliferation, migration, and invasion of human glioblastoma cells. PMID: 28168193
7. These data show that exposure to an allogeneic stimulus is not needed to cause a marked rise in PIBF, merely progesterone alone is sufficient. PMID: 26634256
8. Maternal serum progesterone-induced blocking factor (PIBF) in the prediction of preterm birth. PMID: 25818991
9. progesterone-induced blocking factor is intracellularly expressed by the cultured cells from Glioblastoma PMID: 24474429
10. Progesterone-induced blocking factor is hormonally regulated in human astrocytoma cells, and increases their growth through the IL-4R/JAK1/STAT6 pathway PMID: 25218441
11. decreased kisspeptin and PIBF expressions in trophoblasts and deciduas are associated with recurrent spontaneous abortion PMID: 24225150
12. reduced expression during late pregnancy and resorption PMID: 24325791
13. Data indicate that silencing of progesterone-induced blocking factor (PIBF) increased invasiveness as well as MMP-2,-9 secretion of HTR8/SVneo trophoblast, and decreased those of HT-1080 cells. PMID: 23807209
14. CEP90 physically interacts with PCM-1 at centriolar satellites, and this interaction is essential for centrosomal accumulation of the centriolar satellites and eventually for primary cilia formation. PMID: 23110211
15. Suggest that urinary PIBF levels may predict graft rejection in transplant recipients. PMID: 22172828
16. increased serum levels after dydrogesterone supplementation in women with threatened preterm delivery; positive correlation with the length of gestation PMID: 22032897
17. CEP90 was characterized as a component of pericentriolar satellites. PMID: 21224392
18. PIBF affects the expression of leptin and its receptor, and PIBF expression is inversely related to trophoblast invasiveness. PMID: 21632119
19. promotes secretion of type 2 cytkines by activated lymphocytes from pregnant woman PMID: 19371956
20. The 48-kDa N-terminal part of PIBF is biologically active, and the part of the molecule responsible for modulating natural killer cell activity is encoded by exons 2-4. PMID: 14634107
21. PIBF production is a characteristic feature of normal pregnancy, and determination of PIBF concentration in urine might be of use for the diagnosis of threatened premature pregnancy termination. PMID: 15269099
22. progesterone induced blocking factor overexpression is associated with breast neoplasms PMID: 15305375
23. PIBF phosphorylates PKC via binding to the IL-4R, without affecting intracellular Ca(++). These findings explain the mechanism by which PIBF supports a Th2 dominant cytokine pattern. PMID: 16433831
24. PIBF concentrations in urine and serum of patients with threatened abortion were significantly lower than in healthy pregnant women. PMID: 19290853

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May be associated with microcephaly.

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Secreted.; [Isoform 1]: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Secreted.; [Isoform 4]: Secreted.

Expressed at highest levels in testis. Moderate expression is detected in spleen, thymus, prostate, ovary, small intestine, and colon. Expressed in the first trimester pregnancy decidua. Localized to extravillous cytotrophoblast (at protein level). Also f

HGNC: 23352

OMIM: 607532

KEGG: hsa:10464

STRING: 9606.ENSP00000317144

UniGene: Hs.441926