Human chemokine (C-X-C motif) ligand 17 (CXCL17) ELISA kit

Human chemokine (C-X-C motif) ligand 17 (CXCL17) ELISA kit

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中文名稱：

人趨化因子配體17(CXCL17)酶聯免疫試劑盒
貨號：

CSB-EL006246HU
規格：

96T/48T
價格：

￥3600/￥2500
促銷：
其他：

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產品描述：

人趨化因子配體17(CXCL17)酶聯免疫試劑盒（CSB-EL006246HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織培養上清液、尿液、組織勻漿樣本中的CXCL17含量。CXCL17是一種趨化因子，在免疫調節等生理過程中發揮作用。目前研究聚焦于其在腫瘤微環境里對免疫細胞的趨化，影響腫瘤免疫逃逸，還探索其與炎癥性疾病的關聯，想通過揭示機制為開發腫瘤及炎癥治療新策略提供依據。試劑盒檢測范圍為125 pg/mL-8000 pg/mL，可廣泛應用于細胞因子網絡研究、炎癥相關疾病機制探索、腫瘤免疫微環境分析等科研領域，為體外實驗中的CXCL17表達水平檢測提供標準化工具，支持藥物開發或病理機制研究中的生物標志物分析需求。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
別名：

CXCL17 ELISA Kit; VCC1 ELISA Kit; UNQ473/PRO842C-X-C motif chemokine 17 ELISA Kit; 6-Cys CXCL17 ELISA Kit; Dendritic cell and monocyte chemokine-like protein ELISA Kit; DMC ELISA Kit; VEGF coregulated chemokine 1) [Cleaved into: 4-Cys CXCL17] ELISA Kit
縮寫：

CXCL17
Uniprot No.：

Q6UXB2
種屬：

Homo sapiens (Human)
樣本類型：

serum, plasma, cell culture supernates, urine, tissue homogenates
檢測范圍：

125 pg/mL-8000 pg/mL
靈敏度：

31.25 pg/mL
反應時間：

1-5h
樣本體積：

50-100ul
檢測波長：

450 nm
研究領域：

Immunology
測定原理：

quantitative
測定方法：

Sandwich

精密度：

線性度：

To assess the linearity of the assay, samples were spiked with high concentrations of human CXCL17 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
	Sample	Serum(n=4)
1:1	Average %	88
	Range %	82-94
1:2	Average %	90
	Range %	84-95
1:4	Average %	96
	Range %	92-100
1:8	Average %	93
	Range %	90-96

回收率：

The recovery of human CXCL17 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.

Sample Type	Average % Recovery	Range
Serum (n=5)	96	90-102
EDTA plasma (n=4)	98	90-104

標準曲線：

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

pg/ml	OD1	OD2	Average	Corrected
8000	2.174	2.199	2.187	2.022
4000	1.459	1.499	1.479	1.314
2000	0.999	0.973	0.986	0.821
1000	0.638	0.692	0.665	0.500
500	0.450	0.468	0.459	0.294
250	0.324	0.342	0.333	0.168
125	0.247	0.259	0.253	0.088
0	0.164	0.166	0.165

數據處理：

ELISA操作視頻及標曲繪制軟件下載
貨期：

3-5 working days

CXCL17-derived CD11b+Gr-1+ myeloid-derived suppressor cells contribute to lung metastasis of breast cancer through platelet-derived growth factor-BB Hsu YL, et al,Breast Cancer Research,2019

功能：

Chemokine that acts as chemoattractant for monocytes, macrophages and dendritic cells. Plays a role in angiogenesis and possibly in the development of tumors. Acts as an anti-inflammatory in the stomach. May play a role in the innate defense against infections. Activates the C-X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions.; seems exhibit much higher chemoattractant potency on monocytes and macrophages than 6-Cys CXCL17.
基因功能參考文獻：
1. High Lymph node CXCL17 messenger RNA is associated with colon cancer. PMID: 30198422
2. High expression of CXCL17 correlates with shorter overall survival of breast cancer patients.CXCL17 interacts with CXCR8 in breast cancer cells. PMID: 28943434
3. CXCL17 attenuates Imiquimod -induced psoriasis-like skin inflammation by recruiting myeloid-derived suppressor cells and regulatory T cells , which may be important for regulating excessive inflammation in psoriasis skin. PMID: 28389593
4. This article shows that GPR35 is the receptor of CXCL17. PMID: 25411203
5. CXCL17 production correlated with adverse immune infiltration and might be an important target for anti-HCC therapies. PMID: 25303284
6. We conclude that CXCL17 is an antimicrobial mucosal chemokine that may play a role in the pathogenesis of interstitial lung diseases PMID: 22611239
7. these results suggest that VCC-1 is involved in cisplatin-induced apoptosis of HepG2 cells, and also provides some evidence for VCC-1 as a potential cellular target for chemotherapy. PMID: 22425983
8. An Fc-fusion protein of 35kDa with a modified human immunoglobulin IgG1 Fc domain is capable of inhibiting CC chemokine-induced calcium flux, chemotaxis, and beta-arrestin recruitment in primary macrophages and transfected cells. PMID: 21586597
9. Immune surveillance occurs during the early intraepithelial stages of human pancreatic carcinogenesis and is mediated by expression of CXCL17 and ICAM2. PMID: 20955708
10. DMC induces migration of monocytes and immature dendritic cells. Expression studies show that DMC is constitutively expressed in lung, suggesting a potential role for DMC in recruiting monocytes and dendritic cells from blood into lung parenchyma PMID: 16455961
11. VCC1 plays a role in angiogenesis and possibly in the development of tumors in some tissue types PMID: 16989774
12. These results strongly suggest that VCC-1 plays an important role in hepatocellular carcinoma cell invasion and tumor growth. PMID: 19657564
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亞細胞定位：

Secreted.
蛋白家族：

Intercrine alpha (chemokine CxC) family
組織特異性：

Detected in trachea, stomach, lung and skeletal muscle. Detected in intestine and in normal and asthmatic lung (at protein level). Breast tumors showed 3- to 24-fold up-regulation.
數據庫鏈接：

HGNC: 19232

OMIM: 611387

KEGG: hsa:284340

STRING: 9606.ENSP00000472467

UniGene: Hs.445586

Intra-assay Precision (Precision within an assay): CV%<8%

Three samples of known concentration were tested twenty times on one plate to assess.

Inter-assay Precision (Precision between assays): CV%<10%

Three samples of known concentration were tested in twenty assays to assess.