Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors and protects myocardium from pressure overload. May contribute to spinal presynaptic hypersensitivity and neuropathic pain states after peripheral nerve injury. May play a role in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury in a NOTCH1-dependent manner.

1. establish a novel molecular mechanism by which miR-148a-3p upregulates Tsp-4 expression in tenocytes to promote angiogenesis by targeting KLF6, which could be helpful for the treatment of tendinopathy in the future PMID: 29807011
2. Findings indicate that loss of miR-142 results in the over-expression of THBS4, which enhances HCC migration and vascular invasion. PMID: 28177895
3. the present study demonstrates that THBS4 and lncRNA-THBS4-003 serve a significant role in PCa proliferation and migration via the MMP-9 and p38 MAPK signaling pathway. PMID: 27357608
4. The THBS4 A387P polymorphism was associated with coronary artery disease in American population. PMID: 25976449
5. Tsp4 functions as an ECM scaffold at myotendinous junctions, with potential therapeutic uses in tendon strengthening and repair PMID: 24941943
6. THBS4 expression in breast cancer-associated extracellular matrix contributes to the activated stromal response exhibited during tumour progression PMID: 23942617
7. the balancing selection target in THBS4 is likely represented by one or more variants that regulate tissue-specific and sex-specific gene expression PMID: 23420636
8. The results of thid study suggested that injury-induced spinal TSP4 may contribute to spinal presynaptic hypersensitivity and neuropathic pain states. PMID: 22745497
9. genetic polymorphism predicts cardiovascular risk in postinfarction patients with high HDL cholesterol and C-reactive protein levels PMID: 22011848
10. Identify THBS4 as a powerful marker for diffuse-type gastric adenocarcinomas and to provide an initial characterization of its expression in the course of this disease. PMID: 21701537
11. High THBS4 methylation resulting in inactivation of the gene is associated with colorectal cancer. PMID: 20846368
12. thrombospondin-4 C-terminal peptide has a role in stimulating erythroid cell proliferation PMID: 15474480
13. Promoter hypermethylation of thrombospondin 4 is associated with cutaneous T-cell lymphoma PMID: 15897551
14. Homozygosity for thrombospondin-4 1186C (Arg387Pro) variant is a risk factor for myocardial infarction especially in older women. PMID: 16923428
15. The functional analysis of the rat counterpart. PMID: 7490284

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Endoplasmic reticulum. Sarcoplasmic reticulum. Secreted. Secreted, extracellular space. Secreted, extracellular space, extracellular matrix.

Thrombospondin family

HGNC: 11788

OMIM: 600715

KEGG: hsa:7060

STRING: 9606.ENSP00000339730

UniGene: Hs.211426