Human T-complex protein 1 subunit epsilon(CCT5) ELISA kit

說明書下載

中文名稱：

人T復(fù)合物蛋白1亞基ε(CCT5)酶聯(lián)免疫試劑盒
貨號：

CSB-EL004862HU
規(guī)格：

96T/48T
價格：

￥3600/￥2500
其他：

CUSABIO Wins 2024 Bioz Rapid Star? Award in the ELISA category

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產(chǎn)品描述：

人T復(fù)合物蛋白1亞基ε(CCT5)酶聯(lián)免疫試劑盒（CSB-EL004862HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿,組織勻漿、細胞裂解物樣本中的CCT5含量。CCT5是一種重要靶點。它屬于分子伴侶蛋白家族，在細胞內(nèi)參與眾多蛋白質(zhì)的折疊過程。目前研究關(guān)注其在細胞內(nèi)穩(wěn)態(tài)維持和疾病發(fā)生發(fā)展中的作用機制，了解其與疾病的關(guān)聯(lián)，有望為相關(guān)疾病的治療提供新的靶點和策略。試劑盒檢測范圍為15.6 pg/mL-1000 pg/mL，適用于體外培養(yǎng)細胞模型、動物組織或液體樣本中CCT5表達水平的動態(tài)監(jiān)測，為探索其在細胞增殖、凋亡調(diào)控或疾病模型中的功能提供定量分析工具，廣泛用于分子生物學(xué)、病理機制及藥物干預(yù)效果評估等基礎(chǔ)研究領(lǐng)域。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
別名：

CCT 5 ELISA Kit; CCT epsilon ELISA Kit; CCT-epsilon ELISA Kit; CCT5 ELISA Kit; CCTE ELISA Kit; CCTepsilon ELISA Kit; Chaperonin containing T-complex polypeptide 1; subunit 5 ELISA Kit; Chaperonin containing TCP 1 epsilon ELISA Kit; Chaperonin containing TCP 1 subunit 5 ELISA Kit; Chaperonin containing TCP 1 subunit 5 epsilon ELISA Kit; Chaperonin containing TCP1 epsilon ELISA Kit; Chaperonin containing TCP1 subunit 5 ELISA Kit; Chaperonin containing TCP1 subunit 5 epsilon ELISA Kit; KIAA0098 ELISA Kit; T complex protein 1 epsilon subunit ELISA Kit; T complex protein 1 subunit epsilon ELISA Kit; T-complex protein 1 subunit epsilon ELISA Kit; TCP 1 epsilon ELISA Kit; TCP-1-epsilon ELISA Kit; TCP1epsilon ELISA Kit; TCPE ELISA Kit; TCPE_HUMAN ELISA Kit
縮寫：

CCT5
Uniprot No.：

P48643
種屬：

Homo sapiens (Human)
樣本類型：

serum, plasma,tissue homogenates, cell lysates
檢測范圍：

15.6 pg/mL-1000 pg/mL
靈敏度：

3.9 pg/mL
反應(yīng)時間：

1-5h
樣本體積：

50-100ul
檢測波長：

450 nm
研究領(lǐng)域：

Signal Transduction
測定原理：

quantitative
測定方法：

Sandwich
數(shù)據(jù)處理：

ELISA操作視頻及標曲繪制軟件下載
貨期：

3-5 working days

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功能：

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
基因功能參考文獻：
1. CCT5 complex caps mutant mHTT fibrils at their tips and encapsulates mHTT oligomers, providing a structural description of the inhibition of mHTTQ46-Ex1 by CCT5 complex and a shared mechanism of mHTT inhibition between TRiC chaperonin and the CCT5 complex PMID: 25995452
2. H147R CCT5 was not as efficient in chaperoning these substrates as wild type CCT5. PMID: 25124038
3. introduction of the truncated human CCT epsilon subunit into yeast cells PMID: 22232265
4. A missense mutation within the CCT5 gene is associated with autosomal recessive mutilating sensory neuropathy with spastic paraplegia. PMID: 16399879
相關(guān)疾病：

Neuropathy, hereditary sensory, with spastic paraplegia, autosomal recessive (HSNSP)
亞細胞定位：

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
蛋白家族：

TCP-1 chaperonin family
數(shù)據(jù)庫鏈接：

HGNC: 1618

OMIM: 256840

KEGG: hsa:22948

STRING: 9606.ENSP00000280326

UniGene: Hs.1600

Human T-complex protein 1 subunit epsilon(CCT5) ELISA kit

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