Human Secretoglobin family 3A member 2(SCGB3A2) ELISA kit
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中文名稱：人分泌球蛋白3A成員2(SCGB3A2)酶聯(lián)免疫試劑盒
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貨號(hào)：CSB-EL020819HU
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規(guī)格：96T/48T
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價(jià)格：￥3600/￥2500
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其他：
產(chǎn)品詳情
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產(chǎn)品描述：人分泌球蛋白3A成員2(SCGB3A2)酶聯(lián)免疫試劑盒（CSB-EL020819HU）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿樣本中的SCGB3A2含量。SCGB3A2是重要靶點(diǎn)。它是分泌蛋白，在呼吸道上皮細(xì)胞表達(dá)。研究發(fā)現(xiàn)其與肺部疾病如肺纖維化、哮喘等密切相關(guān)。機(jī)制上，它能調(diào)節(jié)炎癥反應(yīng)、維持上皮細(xì)胞穩(wěn)態(tài)，針對(duì)其開(kāi)發(fā)的藥物可干預(yù)相關(guān)疾病進(jìn)程，有潛在治療價(jià)值。試劑盒檢測(cè)范圍為46.88 pg/mL-3000 pg/mL，本產(chǎn)品適用于基礎(chǔ)醫(yī)學(xué)研究中SCGB3A2蛋白表達(dá)動(dòng)力學(xué)分析，如在呼吸道疾病模型中的功能探究、免疫調(diào)節(jié)機(jī)制研究或作為潛在生物標(biāo)志物的篩選驗(yàn)證，為探索其在肺部炎癥、過(guò)敏性疾病或腫瘤微環(huán)境中的作用提供可靠檢測(cè)工具，所有應(yīng)用場(chǎng)景僅限于科研用途。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書(shū)。
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別名：LU103 ELISA Kit; Pneumo secretory protein 1 ELISA Kit; PnSP-1 ELISA Kit; PNSP1 ELISA Kit; SCGB3A2 ELISA Kit; Secretoglobin family 3A member 2 ELISA Kit; SG3A2_HUMAN ELISA Kit; UGRP1 ELISA Kit; Uteroglobin-related protein 1 ELISA Kit
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縮寫(xiě)：SCGB3A2
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Uniprot No.：
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種屬：Homo sapiens (Human)
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樣本類型：serum, plasma, tissue homogenates
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檢測(cè)范圍：46.88 pg/mL-3000 pg/mL
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靈敏度：11.72 pg/mL
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反應(yīng)時(shí)間：1-5h
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樣本體積：50-100ul
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檢測(cè)波長(zhǎng)：450 nm
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研究領(lǐng)域：Epigenetics and Nuclear Signaling
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測(cè)定原理：quantitative
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測(cè)定方法：Sandwich
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精密度：
Intra-assay Precision (Precision within an assay): CV%<8% Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV%<10% Three samples of known concentration were tested in twenty assays to assess. -
線性度：
To assess the linearity of the assay, samples were spiked with high concentrations of human SCGB3A2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay. Sample Serum(n=4) 1:1 Average % 95 Range % 91-98 1:2 Average % 88 Range % 81-92 1:4 Average % 104 Range % 98-111 1:8 Average % 97 Range % 83-93 -
回收率：
The recovery of human SCGB3A2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section. Sample Type Average % Recovery Range Serum (n=5) 91 85-99 EDTA plasma (n=4) 95 89-100 -
標(biāo)準(zhǔn)曲線：
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed. 
pg/ml OD1 OD2 Average Corrected 3000 2.703 2.752 2.728 2.606 1500 1.906 1.866 1.886 1.764 750 1.128 1.200 1.164 1.042 375 0.545 0.539 0.542 0.420 187.5 0.316 0.332 0.324 0.202 93.75 0.205 0.208 0.207 0.085 46.88 0.186 0.200 0.193 0.071 0 0.121 0.122 0.122 -
數(shù)據(jù)處理：
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貨期：3-5 working days
引用文獻(xiàn)
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靶點(diǎn)詳情
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功能：Secreted cytokine-like protein. Binds to the scavenger receptor MARCO. Can also bind to pathogens including the Gram-positive bacterium L.monocytogenes, the Gram-negative bacterium P.aeruginosa, and yeast. Strongly inhibits phospholipase A2 (PLA2G1B) activity. Seems to have anti-inflammatory effects in respiratory epithelium. Also has anti-fibrotic activity in lung. May play a role in fetal lung development and maturation. Promotes branching morphogenesis during early stages of lung development. In the pituitary, may inhibit production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH).
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基因功能參考文獻(xiàn)：
- rs151333009 SNP showed a monomorphic genotype. Two promoter SNPs (rs6882292, -659 G/A and rs1368408, -112 G/A) showed significant association with asthma. These results suggest that the promoter SNPs (rs6882292 and rs1368408) of SCGB3A2 gene may contribute to susceptibility to asthma in a Korean population. PMID: 28422086
- This meta-analysis suggests that SCGB3A2 polymorphism at positions -112G>A was associated with Graves' disease both in Chinese and Caucasian population. PMID: 23934357
- the SCGB3A2 -112G >A polymorphism may be considered as a likely marker linking susceptibility to allergy/asthma and Graves' disease PMID: 21170691
- Reduced production of UGRP1, which is likely due, at least in part, to a local cytokine environment, may contribute to the hyper-inflammation in chronic rhinosinusitis and correlates with response to surgery. PMID: 21385388
- This study documents the association between polymorphisms in UGRP1 and the common cold, suggesting a potential role in its pathogenesis. PMID: 21410962
- Results demonstrate that SCGB3A2 is a useful marker for diagnosis of pulmonary tumors both in mice and humans. PMID: 20466451
- pattern of UGRP-1 concentration resembled that of Clara cell protein, both proteins occurring in high concentrations in amniotic fluid, sputum and BALF and in much lower concentrations in serum and urine PMID: 20843168
- association was detected between SCGB3A2 and U.K. Caucasian Graves' disease subjects but the size of effect was smaller than that seen in the Oriental population (odds ratio = 1.28-1.73). PMID: 20210668
- polymorphism in the human UGRP1 gene promoter that regulates transcription is associated with an increased risk of asthma PMID: 11813133
- By in situ hybridization, UGRP1 is found to be expressed by lung Clara-like cells in the bronchial epithelium and up-regulated in lung epithelium of a patient with cystic fibrosis. PMID: 12847263
- results demonstrate that interleukin-10 induces uteroglobin related protein 1(UGRP1) gene expression in lung epithelial cells through transcription factor T/EBP/NKX2.1-dependent pathway PMID: 15485815
- plasma UGRP1 levels were associated with the G-112A UGRP1 gene promoter polymorphism and the severity of asthma PMID: 18089940
- results suggest that the -112G/A polymorphism does not play a significant role in the genetic predisposition of the UGRP1 gene in atopic asthma in the Sicilian population PMID: 18201431
- SCGB3A2 gene may contribute to Graves' disease susceptibility. PMID: 19126779
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亞細(xì)胞定位：Secreted.
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蛋白家族：Secretoglobin family, UGRP subfamily
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組織特異性：Highly expressed in lung and trachea. Detected throughout the airway epithelium in lung, with slightly higher expression in large airways. Found in lung submucosal gland acinus where it localizes to serous-like cells. Probably expressed in club/Clara cell
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