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中文名稱：人L乳酸脫氫酶B鏈(LDHB)酶聯免疫試劑盒
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貨號：CSB-EL012841HU
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規格：96T/48T
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價格：￥3600/￥2500
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促銷：
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其他：
產品詳情
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產品描述：人L乳酸脫氫酶B鏈(LDHB)酶聯免疫試劑盒（CSB-EL012841HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿、腦脊液（CSF）、尿液.樣本中的LDHB含量。LDHB即乳酸脫氫酶B，是乳酸脫氫酶的亞基之一。它參與糖酵解和乳酸代謝過程。研究發現其在多種腫瘤中表達異常，可能通過調節細胞代謝微環境、影響腫瘤細胞增殖凋亡等機制，在腫瘤發生發展中發揮作用，是潛在的腫瘤治療靶點。試劑盒檢測范圍為23.5 mU/mL-1500 mU/mL，該產品適用于體外科研實驗中多種生物樣本的LDHB活性檢測，可服務于細胞代謝研究、疾病模型能量通路分析、腫瘤微環境評估等基礎研究領域。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
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別名：Epididymis secretory protein Li 281 ELISA Kit; HEL S 281 ELISA Kit; L lactate dehydrogenase B chain ELISA Kit; L-lactate dehydrogenase B chain ELISA Kit; Lactate Dehydrogenase B ELISA Kit; Lactate dehydrogenase H chain ELISA Kit; LDH B ELISA Kit; LDH H ELISA Kit; LDH heart subunit ELISA Kit; LDH-B ELISA Kit; LDH-H ELISA Kit; LDHB ELISA Kit; LDHB_HUMAN ELISA Kit; LDHBD ELISA Kit; LDHH ELISA Kit; Renal carcinoma antigen NY REN 46 ELISA Kit; Renal carcinoma antigen NY-REN-46 ELISA Kit; TRG-5 ELISA Kit; TRG5 ELISA Kit
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縮寫：
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Uniprot No.：
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種屬：Homo sapiens (Human)
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樣本類型：serum, plasma, tissue homogenates, cerebrospinal fluid (CSF), urine.
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檢測范圍：23.5 mU/mL-1500 mU/mL
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靈敏度：5.8 mU/mL
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反應時間：1-5h
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樣本體積：50-100ul
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檢測波長：450 nm
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研究領域：Metabolism
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測定原理：quantitative
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測定方法：Sandwich
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精密度：
Intra-assay Precision (Precision within an assay): CV%<8% Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV%<10% Three samples of known concentration were tested in twenty assays to assess. -
線性度：
To assess the linearity of the assay, samples were spiked with high concentrations of human LDHB in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay. Sample Serum(n=4) 1:1 Average % 89 Range % 84-93 1:2 Average % 100 Range % 97-103 1:4 Average % 87 Range % 84-90 1:8 Average % 102 Range % 98-106 -
回收率：
The recovery of human LDHB spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section. Sample Type Average % Recovery Range Serum (n=5) 103 100-106 EDTA plasma (n=4) 89 85-92 -
標準曲線：
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed. 
mU/ml OD1 OD2 Average Corrected 1500 2.184 2.203 2.194 2.038 750 1.706 1.697 1.702 1.546 375 1.215 1.241 1.228 1.072 187.5 0.757 0.738 0.748 0.592 94 0.442 0.468 0.455 0.299 47 0.319 0.298 0.309 0.153 23.5 0.244 0.231 0.238 0.082 0 0.159 0.153 0.156 -
數據處理：
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貨期：3-5 working days
引用文獻
產品評價
相關產品
靶點詳情
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基因功能參考文獻：
- High LDHB expression is significantly associated with the level of serum LDH and better clinical outcomes in lung squamous cell carcinoma PMID: 28756978
- this study shows that low base line lactate dehydrogenase is linked with a better tumor response, and that prolonged overall survival and progression-free survival are observed for patients under ipilimumab treatment with no increase in lactate dehydrogenase PMID: 27485076
- our study examines the inclusion of salivary LDH as potential diagnostic parameter and therapeutic index in Oral squamous cell carcinoma PMID: 26577856
- addition of exogenous lactic acid to growth media was sufficient to induce cell death that could be inhibited by the expression of LDHB. the results suggest that lactate dehydrogenase is a general suppressor of programmed cell death in yeast. PMID: 26032856
- The aim of this study was to demonstrate the effects of 6-week low-intensity training on changes in indicators of aerobic capacity and on HSPA1A, HSPB1, and LDHb expression in white blood cells in high level rowers. PMID: 26214432
- Lactate dehydrogenase B is associated with the response to neoadjuvant chemotherapy in oral squamous cell carcinoma. PMID: 25973606
- The readthrough-extended lactate dehydrogenase subunit LDHBx can also co-import LDHA, the other LDH subunit, into peroxisomes. PMID: 25247702
- We were able to provide evidence that methylation of HLTF and especially HPP1 detected in serum is strongly correlated with cell death in CRC using LDH as surrogate marker PMID: 24708595
- This meta-analysis shows that high serum LDH level is obviously associated with lower overall survival rate in patients with osteosarcoma, and it is an effective biomarker of prognosis. PMID: 24682390
- These observations support prospective clinical evaluation of LDHB as a predictive marker of response for patients with breast cancer receiving neoadjuvant chemotherapy. PMID: 23697991
- This study identifies LDHB as a regulator of cell proliferation in a subset of lung adenocarcinoma and may provide a novel therapeutic approach for treating lung cancer PMID: 23224736
- LDH concentrations in nasopharyngeal secretions are positively associated with acute otitis media risk. PMID: 23202721
- Loss of LDH-B expression is an early and frequent event in human breast cancer occurring due to promoter methylation, and is likely to contribute to an enhanced glycolysis of cancer cells under hypoxia. PMID: 23437403
- ata indicate that serum lactic dehydrogenase (S-LDH) appears to be a significant independent prognostic index in patients with metastatic nasopharyngeal carcinoma (NPC). PMID: 23266049
- Patients with severe vaso-occlusive crisis were more frequently males, who also had higher white blood cell (WBC) count, procalcitonin (PCT), and lactate dehydrogenase (LDH) levels. PMID: 22892192
- Data reveal that LDHB is upregulated and required only in certain cancer genotypes. PMID: 23139210
- results indicate that histone deacetylase inhibitors upregulate miRNAs, at least some of which act as tumor suppressors. lactate dehydrogenase B, which is regulated by the tumor suppressive miR-375, may therefore act as an oncogene in esophageal squamous cell carcinoma. PMID: 22752059
- Serum lactate dehydrogenase is a prognostic and predictive biomarker for survival benefit conferred by TORC1 inhibition in poor-risk renal cell carcinoma. PMID: 22891270
- Data indicate that serum lactate dehydrogenase (LDH) seemed able to predict clinical outcome for hepatocellular carcinoma (HCC) patients undergoing hepatocellular carcinoma (HCC). PMID: 22461886
- The significant elevation in serum CK [creatine kinase ]and LDH [L-Lactate Dehydrogenase ] activities indicates that these can be used as parameters for screening hypothyroid patients but not hyperthyroid patients. PMID: 22248949
- results confirmed the prognostic roles of LDH-B in urinary bladder urothelial carcinoma. PMID: 22027740
- Results suggest that lactate dehydrogenase B suppression plays an important role in triggering or maintaining the mitochondrial defects and then contributes to cancer cell invasiveness by inducing claudin-1 protein. PMID: 21356207
- Elevated serum LDH isoenzymes and AST indicate a disturbance (of uncertain clinical significance) within multiple extraosseous tissues when there is CLCN7 deficiency. PMID: 20499337
- findings offer proof of concept for targeting LDHB as a therapeutic strategy in cancers driven by aberrant activation of the RTK-PI3K-AKT-mTOR signaling cascade PMID: 21199794
- S100B and LDH are not expressed in sentinel node progression of melanoma PMID: 20592382
- LDHB was elevated in idiopathic myelofibrosis. This isoenzymatic pattern could be expression of a metabolic adaptation. PMID: 17178662
- MYC, LDHB, and CCNB1 may have roles in progression of medulloblastoma PMID: 18593994
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相關疾病：Lactate dehydrogenase B deficiency (LDHBD)
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亞細胞定位：Cytoplasm. Mitochondrion inner membrane; Peripheral membrane protein.
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蛋白家族：LDH/MDH superfamily, LDH family
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數據庫鏈接：
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