Human Cartilage intermediate layer protein 1(CILP) ELISA kit

Human Cartilage intermediate layer protein 1(CILP) ELISA kit

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中文名稱：

人軟骨中間層蛋白1(CILP)酶聯免疫試劑盒
貨號：

CSB-EL005437HU
規格：

96T/48T
價格：

￥3600/￥2500
其他：

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產品描述：

人軟骨中間層蛋白1(CILP)酶聯免疫試劑盒（CSB-EL005437HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的CILP含量。CILP（Contrastive Language-Image Pre-Training）是一種由OpenAI提出的預訓練模型，旨在通過對比學習預訓練語言和圖像的表示，以實現圖像和文本之間的相互理解。該模型通過大量圖像與文本對進行預訓練，采用自監督學習方法，通過度量圖像與文本之間的相似性來提高模型的表現能力。試劑盒檢測范圍為93.75 pg/mL-6000 pg/mL，該產品適用于體外研究軟骨組織工程模型中的基質代謝調控、退行性關節疾病動物模型的生物標志物追蹤，以及臨床前研究中的軟骨修復效果評估等科研場景，為探索軟骨病變機制及潛在干預策略提供可靠工具。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
別名：

Cartilage intermediate layer protein 1 ELISA Kit; Cartilage intermediate layer protein 1 C1 ELISA Kit; Cartilage intermediate layer protein 1 C2 ELISA Kit; cartilage intermediate layer protein ELISA Kit; cartilage intermediate layer protein; nucleotide pyrophosphohydrolase ELISA Kit; Cartilage intermediate-layer protein ELISA Kit; CILP 1 ELISA Kit; CILP ELISA Kit; CILP-1 ELISA Kit; CILP1_HUMAN ELISA Kit; HGNC:1980 ELISA Kit; HsT18872 ELISA Kit
縮寫：

CILP
Uniprot No.：

O75339
種屬：

Homo sapiens (Human)
樣本類型：

serum, plasma, tissue homogenates
檢測范圍：

93.75 pg/mL-6000 pg/mL
靈敏度：

23.4 pg/mL
反應時間：

1-5h
樣本體積：

50-100ul
檢測波長：

450 nm
研究領域：

Signal Transduction
測定原理：

quantitative
測定方法：

Sandwich

精密度：

線性度：

To assess the linearity of the assay, samples were spiked with high concentrations of human CILP in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
	Sample	Serum(n=4)
1:5	Average %	94
	Range %	90-98
1:10	Average %	105
	Range %	100-112
1:20	Average %	84
	Range %	80-88
1:40	Average %	95
	Range %	90-100

回收率：

The recovery of human CILP spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.

Sample Type	Average % Recovery	Range
Serum (n=5)	93	89-98
EDTA plasma (n=4)	98	94-106

標準曲線：

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

pg/ml	OD1	OD2	Average	Corrected
6000	2.098	2.201	2.150	2.027
3000	1.512	1.454	1.483	1.360
1500	0.983	0.934	0.959	0.836
750	0.611	0.643	0.627	0.504
375	0.330	0.338	0.334	0.211
187.5	0.282	0.302	0.292	0.169
93.75	0.192	0.207	0.200	0.077
0	0.125	0.120	0.123

數據處理：

ELISA操作視頻及標曲繪制軟件下載
貨期：

3-5 working days

CILP1 interacting with YBX1 promotes hypertrophic scar formation by suppressing PPARs transcription J Wang, J Du, Y Song, X Tan, J Wu, T Wang,Cell Death & Disease,2025
CILP-1 Is a Biomarker for Backward Failure and Right Ventricular Dysfunction in HFrEF A Weidenhammer,Cells,2023
CILP1 as a biomarker for right ventricular dysfunction in patients with ischemic cardiomyopathy S Keranov,Pulmonary Circulation,2022

功能：

Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage.
基因功能參考文獻：
1. CILP rs2073711 TT is associated with increased risk of symmetrical hand osteoarthritis particularly in individuals with low variation in work tasks. PMID: 29233086
2. Meta-analysis. Our results confirm the positive association between CILP and intervertebral disc degeneration, providing novel clues for clarifying the role of CILP in the development of IVD. PMID: 27359356
3. CILP is involved in the etiology of intervertebral disc degeneration among young adults. PMID: 22107760
4. The researchers found that the single nucleotide polymorphism (1184T/C) of the CILP gene is associated an increased risk of lumbar disc degeneration in male athletes. PMID: 20724643
5. CILP regulates TGF-beta signaling and that this regulation has a crucial role in the etiology and pathogenesis of LDD. PMID: 15864306
6. These observations, together with the finding that CILP protein binds and inhibits TGF-beta1, suggest that CILP and TGF-beta1 may form a functional feedback loop that controls chondrocyte metabolism. PMID: 16413503
7. SNP analysis suggested that the CILP gene is not a major risk factor for symptoms of lumbar disc disease in Finnish or Chinese populations. PMID: 17220213
8. the CILP gene 1184T/C polymorphism is a significant risk factor for lumbar disc degeneration occurrence in Japanese collegiate judo athletes PMID: 19569011
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相關疾病：

Intervertebral disc disease (IDD)
亞細胞定位：

Secreted, extracellular space, extracellular matrix.
組織特異性：

Specifically expressed in cartilage. Localizes in the intermediates layer of articular cartilage but neither in the superficial nor in the deepest regions. Specifically and highly expressed in intervertebral disk tissue. Expression increases with aging in
數據庫鏈接：

HGNC: 1980

OMIM: 603489

KEGG: hsa:8483

STRING: 9606.ENSP00000261883

UniGene: Hs.442180

Intra-assay Precision (Precision within an assay): CV%<8%

Three samples of known concentration were tested twenty times on one plate to assess.

Inter-assay Precision (Precision between assays): CV%<10%

Three samples of known concentration were tested in twenty assays to assess.