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中文名稱：犬胸腺活化調(diào)節(jié)趨化因子(TARC/CCL17)酶聯(lián)免疫試劑盒
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貨號：CSB-E17792c
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規(guī)格：96T/48T
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價格：￥3800/￥2500
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其他：
產(chǎn)品詳情
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產(chǎn)品描述：犬胸腺活化調(diào)節(jié)趨化因子(TARC/CCL17)酶聯(lián)免疫試劑盒（CSB-E17792c）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的TARC/CCL17含量。TARC/CCL17是重要的靶點。它是一種趨化因子，在免疫系統(tǒng)中發(fā)揮關鍵作用。其異常表達與多種疾病如特應性皮炎、哮喘等相關。研究機制主要聚焦于其與受體結合，介導免疫細胞遷移、活化，進而影響疾病的發(fā)生發(fā)展，為相關疾病治療提供潛在方向。試劑盒檢測范圍為23.5 pg/mL-1500 pg/mL，該產(chǎn)品可為犬類過敏性皮炎模型研究、呼吸道炎癥機制探索、免疫調(diào)節(jié)藥物開發(fā)等科研方向提供可靠數(shù)據(jù)支持，尤其適用于動態(tài)監(jiān)測疾病進程中趨化因子表達變化或評估實驗性治療干預效果，為深入解析犬類免疫調(diào)控網(wǎng)絡提供技術工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
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別名：CCL17 ELISA Kit; TARCC-C motif chemokine 17 ELISA Kit; CC chemokine TARC ELISA Kit; Small-inducible cytokine A17 ELISA Kit; Thymus and activation-regulated chemokine ELISA Kit
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縮寫：TARC/CCL17
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Uniprot No.：
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種屬：Canis lupus familiaris (Dog) (Canis familiaris)
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樣本類型：serum, plasma, tissue homogenates
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檢測范圍：23.5 pg/mL-1500 pg/mL
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靈敏度：5.86 pg/mL
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反應時間：1-5h
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樣本體積：50-100ul
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檢測波長：450 nm
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研究領域：Immunology
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測定原理：quantitative
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測定方法：Sandwich
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精密度：
Intra-assay Precision (Precision within an assay): CV%<8% Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV%<10% Three samples of known concentration were tested in twenty assays to assess. -
線性度：
To assess the linearity of the assay, samples were spiked with high concentrations of canine TARC in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay. Sample Serum(n=4) 1:1 Average % 87 Range % 84-90 1:2 Average % 102 Range % 97-107 1:4 Average % 91 Range % 85-97 1:8 Average % 95 Range % 91-99 -
回收率：
The recovery of canine TARC spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section. Sample Type Average % Recovery Range Serum (n=5) 96 92-99 EDTA plasma (n=4) 100 97-103 -
標準曲線：
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed. 
pg/ml OD1 OD2 Average Corrected 1500 1.908 2.005 1.957 1.801 750 1.179 1.205 1.192 1.036 375 0.734 0.738 0.736 0.580 187.5 0.415 0.436 0.426 0.270 94 0.311 0.328 0.320 0.164 47 0.231 0.245 0.238 0.082 23.5 0.198 0.189 0.194 0.038 0 0.155 0.157 0.156 -
數(shù)據(jù)處理：
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貨期：3-5 working days
引用文獻
- Anti-CCR4 treatment depletes regulatory T cells and leads to clinical activity in a canine model of advanced prostate cancer S Maeda,Journal for Immunotherapy of Cancer,2022
- BRAF Mutation Associates CCL17 Expression and Regulatory T Cell Recruitment in Urothelial Carcinoma of Dogs. S Maeda,Veterinary Pathology,2020
產(chǎn)品評價
相關產(chǎn)品
靶點詳情
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功能：Chemotactic factor for t lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4 and CCR8.
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基因功能參考文獻：
- The present results suggest that TNF-alpha-induced CCL17 mRNA transcription in canine keratinocytes is positively regulated by p38 but negatively controlled by ERK. PMID: 20837364
- This study suggests that interferon-gamma may suppress granulocyte-macrophage colony stimulating factor production from canine keratinocytes, although further studies are required to confirm this. PMID: 20860556
- Inflammatory cytokines are important inducing factors for the production of CCL17 in the lesional skin of dogs with atopic dermatitis. atopic dermatitis. PMID: 20022349
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亞細胞定位：Secreted.
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蛋白家族：Intercrine beta (chemokine CC) family
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組織特異性：Expressed in thymus, spleen, lymph node, lung and heart.
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數(shù)據(jù)庫鏈接：
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