PLG是一種廣泛存在于人體內的血漿蛋白，最近的研究表明PLG在多種疾病的發生和發展中可能發揮著重要的作用。

Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.

1. SUPA formed a higher avidity complex (118-fold) with bovine Pg than with human Pg and non-proteolytically activated bovine but not human Pg. PMID: 22518846
2. The plasminogen/plasminogen activator/plasmin system is activated during gamete interaction and regulates the sperm entry into the oocyte. PMID: 22177313
3. The current study suggests the existence of an active TNF-alpha-plasminogen-plasmin autocrine/paracrine loop on the massively infiltrated polymorphonuclear neutrophils inside udders of drying-off cows. PMID: 19638263
4. examination of interaction with streptococcal plasminogen activator PauA PMID: 15351638

Secreted.

Peptidase S1 family, Plasminogen subfamily

KEGG: bta:280897

STRING: 9913.ENSBTAP00000001674

UniGene: Bt.306