Recombinant Rat Growth-regulated alpha protein (Cxcl1)
In Stock-
中文名稱:Recombinant Rat Growth-regulated alpha protein(Cxcl1) (Active)
-
貨號:CSB-AP001391RA
-
說明書:
-
規格:¥852
-
圖片:
-
其他:
產品詳情
-
純度:>97% as determined by SDS-PAGE.
-
內毒素:Less than 1.0 EU/μg as determined by LAL method.
-
生物活性:Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using rat neutrophils is in a concentration range of 10-100 ng/ml.
-
基因名:
-
Uniprot No.:
-
別名:Cxcl1; Cinc1; Gro; Scyb1Growth-regulated alpha protein; C-X-C motif chemokine 1; Cytokine-induced neutrophil chemoattractant 1; CINC-1; Platelet-derived growth factor-inducible protein KC
-
種屬:Rattus norvegicus (Rat)
-
蛋白長度:Full Length of Mature Protein
-
來源:E.Coli
-
分子量:7.8 kDa
-
表達區域:25-96aa
-
氨基酸序列APVANELRCQ CLQTVAGIHF KNIQSLKVMP PGPHCTQTEV IATLKNGREA CLDPEAPMVQ KIVQKMLKGV PK
-
蛋白標簽:Tag-Free
-
產品提供形式:Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
緩沖液:0.2 μm filtered concentrated solution in 20 mM PB, 150 mM NaCl, pH 7.4 lyophilized
-
儲存條件:Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
-
保質期:The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期:5-10 business days
-
Datasheet & COA:Please contact us to get it.
相關產品
靶點詳情
-
功能:Has chemotactic activity for neutrophils. Contributes to neutrophil activation during inflammation.
-
基因功能參考文獻:
- The results showed that after short-term incubation both CXCL1 and CXCL2 can activate TRPV1+/IB4+ DRG neurons by significantly reducing TRPV1 desensitization, while at acute application both chemokines induced an increase in [Ca2+]i although of different amplitudes, in a subset of neurons partially also itch-sensitive in the case of CXCL1, or non-itch sensitive in the case of CXCL2. PMID: 28820395
- remote ischemic preconditioning protects hepatic microcirculation by induction of HO and modulation of cytokine induced neutrophil chemoattractant in hepatic ischemia reperfusion injury PMID: 27672274
- Results results demonstrate that sphingosine-1-phosphate induces Ca(2+) signaling in astrocytes via Gq -coupled receptors S1P2 and S1P3 , followed by Ca(2+) influx through TRPC6 that could activate MAPK signaling, which leads to increased secretion of the proinflammatory or neuroprotective chemokine CXCL1 PMID: 28300348
- aging can reduce the expression of CINC and MCP-1 mRNA in lung tissues, and reduce the infiltration of neutrophils and monocyte-macrophages induced by CINC and MCP-1. This might lead to increased risk of pneumonia in elderly patients. PMID: 24464584
- In opioid-tolerant rats, CXCL1 is up-regulated in CSF; as it is in patients also. PMID: 25383568
- Function of the transient receptor potential vanilloid (TRPV)1 channel is enhanced by dorsal root ganglia inflammation. The effects (decreased tachyphylaxis) are mimicked by incubation with GRO/KC. PMID: 22466126
- CXCL1 inhibition of oligodendrocyte progenitor cell migration is regulated via changes in intracellular calcium flux. PMID: 22554866
- hyperoxia exposure led to a suppression of the HDAC1/HDAC2 expression and activity, and the overall HDAC activity, as well as arrest of alveolarization, and an elevated expression of CINC-1 in the lungs of newborn rats PMID: 21905265
- Advanced glycation end products promote the secretion of MCP-1 and IL-8 in vascular smooth muscle cells. PMID: 21418993
- Severe burn injury activates pulmonary NF-kappaB and leads to secretion of IL8 and TNF alpha in the lung. PMID: 17959522
- In rats with chronic nonbacterial prostatitis, the levels of TNF-alpha and IL-8 in the serum and prostate tissues were significantly lower in the curcumin-treated group than in the positive control group. PMID: 20180411
- ATP-stimulated C6 glioma cells showed enhanced expression of MCP-1 & IL-8; elevated levels of MCP-1 & IL-8 are predicted to enhance mobility of tumor cells & promote recruitment of microglia into developing tumors thereby supporting tumor growth. PMID: 20003523
- These results suggest that IL-6 and CINC-1 contribute to alpha2M production in rats only when IL-6 and CINC-1 act synergistically. PMID: 21030786
- The decreased serum concentration of CINC-1 as neuroprotective agent and increased CINC-2alpha in late stage of Morris hepatoma may be considered for their contribution to cerebellar degeneration. PMID: 20602290
- Rats treated with fullerenes showed a transient significant increase of neutrophils and expression of CINC-1,-2alphabeta and -3. PMID: 20226088
- CINC-1, released at sites of inflammation, mediates inflammatory hyperalgesia in rats via release of sympathomimetic amines. PMID: 12517731
- CINC-1 also functions as an early acute-phase protein after injury to the brain or to peripheral tissues PMID: 12709409
- neutrophil migration induced by IL-8 is dependent on CINC-1 release from mast cells PMID: 12824006
- Data show that TII alveolar epithelial cells produce three of the major proinflammatory CXC chemokines (GRO, CINC-2alpha, and MIP-2) and their cognate receptor CXCR2. PMID: 12829448
- CINC, in contrast to MIP-2, is selectively transported from the lung to the systemic circulation, where it promotes neutrophil migration into the lung in response to a chemotactic stimulus. PMID: 14617513
- reactive oxygen species and lipid peroxidation mainly derived from neutrophils, which are stimulated and mobilized by TNF-alpha and cytokine-induced neutrophil chemoattractant-1 PMID: 15942680
- CINC-1 may contribute to liver repair and regeneration PMID: 16271365
- In summary, hyperalgesia, local PGE2 production, and spinal c-Fos expression occur after CFA-induced inflammation but not after CXCL1- or CXCL2/3-induced, selective PMN recruitment. PMID: 16522746
- results demonstrate that ascorbic acid deficiency elevates the serum, liver and spleen concentrations of cytokine-induced neutrophil chemoattractant-1 (CINC-1 as seen in acute inflammation PMID: 16637227
- Following cecal ligation and puncture CINC-1 production increases in the lung, setting the stage for neutrophil accumulation in lung during sepsis. PMID: 16818791
- activation of PAR-2, as well as PAR-1, can rescue astrocytes from ceramide-induced apoptosis via regulating chemokine GRO/CINC-1 release. PMID: 16942465
- berberine dose-dependently inhibited the expression of CINC-1 induced by LPS and diminished the anterior uveitis. PMID: 17164575
- TNFalpha has in different forms of arthritis, but points out the idea that CINC-1 (the homologue for human IL-8) may constitute a promising target for reactive arthritis management PMID: 17166735
- basal level of calcium is the pre-requisite for GRO/CINC-1 protein synthesis and secretion PMID: 17666044
- Induction of CXCL1 by extracellular matrix and autocrine enhancement by interleukin-1 in rat pancreatic beta-cells. PMID: 17702850
- GGA effectively suppressed the up-regulation of GRO1 messenger ribonucleic acid, and this was validated by Northern hybridization. PMID: 18683011
- This is the first time that centrally injected CINC-1 has been reported to act directly on the pyrogen-sensitive neurons of the preoptic area, promoting a thermoregulatory response that seems to depend on other endogenous pyrogens synthesis and PGE2. PMID: 18694739
- CXCL1 incubation (1.5 nM, overnight) caused marked upregulation of Na+ currents in acutely isolated small diameter rat (adult) sensory neurons in vitro. PMID: 18816377
- The results suggest that GRO/KC has important effects in inflammatory processes via its direct actions on sensory neurons. PMID: 19476648
- CINC-1 is a neutrophil chemoattractant; findings have established that CINC-1 also functions as an early acute-phase protein after injury to the brain or to peripheral tissues. PMID: 12709409
顯示更多
收起更多
-
亞細胞定位:Secreted.
-
蛋白家族:Intercrine alpha (chemokine CxC) family
-
組織特異性:At least expressed in the lung and trachea.
-
數據庫鏈接:
Most popular with customers
-
Recombinant Human Angiotensin-converting enzyme 2 (ACE2), partial,Biotinylated (Active)
Express system: Mammalian cell
Species: Homo sapiens (Human)
-
Recombinant Human B- and T-lymphocyte attenuator (BTLA), partial (Active)
Express system: Mammalian cell
Species: Homo sapiens (Human)
-
Recombinant Human E3 ubiquitin-protein ligase ZNRF3 (ZNRF3), partial (Active)
Express system: Mammalian cell
Species: Homo sapiens (Human)
-
Recombinant Human Complement component C1q receptor (CD93), partial (Active)
Express system: Mammalian cell
Species: Homo sapiens (Human)
-
Recombinant Human Mucin-17 (MUC17), partial (Active)
Express system: Mammalian cell
Species: Homo sapiens (Human)
-
Recombinant Human Desmoglein-3 (DSG3), partial (Active)
Express system: Baculovirus
Species: Homo sapiens (Human)
-
Recombinant Macaca fascicularis lymphocyte antigen 6 family member G6D (LY6G6D) (Active)
Express system: Yeast
Species: Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
-
Recombinant Human Myosin regulatory light chain 12A (MYL12A) (Active)
Express system: E.coli
Species: Homo sapiens (Human)