TFAP2E Antibody, Biotin conjugated
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中文名稱：TFAP2E兔多克隆抗體, Biotin偶聯
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貨號：CSB-PA761516LD01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) TFAP2E Polyclonal antibody
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Uniprot No.：
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基因名：TFAP2E
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別名：TFAP2ETranscription factor AP-2-epsilon antibody; AP2-epsilon antibody; Activating enhancer-binding protein 2-epsilon antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Transcription factor AP-2-epsilon protein (66-175AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation.
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基因功能參考文獻：
- Results showed that lower expression levels of TFAP2E are significantly associated with a shorter survival of patients with neuroblastoma indicating that TFAP2E acts as a tumor suppressor of neuroblastoma. PMID: 28260105
- Hypermethylation of TFAP2E was associated with lack of response to fluorouracil-based chemotherapy, indicating that it might be a potential predictor of treatment response in patients with gastric cancer. PMID: 25810491
- AP-2E was frequently hypermethylated in tumors from patients with colorectal cancer PMID: 24996990
- AP-2epsilon indirectly interacts with the core promoter of COL2A1 and subsequently inhibits its transcriptional activity, thus modulating cartilage development. PMID: 23331625
- TFAP2E hypermethylation is associated with clinical nonresponsiveness to chemotherapy in colorectal cancer. PMID: 22216841
- These findings reveal that Tfap2 activity, mediated redundantly by Tfap2a and Tfap2e, promotes melanophore differentiation in parallel with Mitf by an effector other than Kit. PMID: 20862309
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亞細胞定位：Nucleus.
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蛋白家族：AP-2 family
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組織特異性：Expressed in skin, primary keratinocytes, immortalized keratinocytes, and HeLa cell line.
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數據庫鏈接：
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