SLC22A17 Antibody, Biotin conjugated

說明書

中文名稱：

SLC22A17兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA823881LD01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) SLC22A17 Polyclonal antibody
Uniprot No.：

Q8WUG5
基因名：

SLC22A17
別名：

24p3 receptor antibody; 24p3R antibody; BOCT antibody; BOIT antibody; Brain type organic cation transporter antibody; Brain-type organic cation transporter antibody; hBOIT antibody; Lipocalin-2 receptor antibody; Neutrophil gelatinase associated lipocalin receptor antibody; Neutrophil gelatinase-associated lipocalin receptor antibody; NGAL receptor antibody; NgalR antibody; NGALR2 antibody; NGALR3 antibody; OTTHUMP00000082690 antibody; OTTHUMP00000082691 antibody; Potent brain type organic ion transporter antibody; S22AH_HUMAN antibody; Slc22a17 antibody; Solute carrier family 22 member 17 antibody; Solute carrier family 22 organic cation transporter member 17 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Solute carrier family 22 member 17 protein (1-99AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis.
基因功能參考文獻：
1. Results showed the expression levels of NGAL and NGALR significantly downregulated in clear cell renal cell carcinoma samples. PMID: 30138675
2. Biochemical and Structural Characterization of the Interaction between the Siderocalin NGAL/LCN2 (Neutrophil Gelatinase-associated Lipocalin/Lipocalin 2) and the N-terminal Domain of Its Endocytic Receptor SLC22A17. PMID: 26635366
3. Lipocalin 2 might restore the health and regeneration potential of MSCs by decreasing senescence PMID: 24452457
4. No significant difference was found in the expressions of NGALR mRNA in placenta among moderate preeclampsia group, severe preeclampsia group and control group. PMID: 22932106
5. NGAL and NGALR expression might be served as novel prognostic factors and potential therapeutic targets in Hepatocellular carcinoma. PMID: 22728279
6. This study suggested that NGAL and NGALR expression are frequently up-regulated in gliomas, and are closely associated with poor clinical outcome. PMID: 21184133
7. These results suggested that SLC22A17, in cooperation with LCN2, to be involved in the acquisition of aggressive behavior among endometrial carcinoma cells. PMID: 21763306
8. Neutrophil gelatinase-associated lipocalin receptor (NGALR) is differentially expressed in human glomerular disease and is significantly up-regulated by Il-1beta in HMC via MAPK/ERK activation. PMID: 21305251
9. NGALR hypomethylation contributes to its expression in esophageal carcinomas and that this overexpression may play a role in the pathogenesis of esophageal carcinomas. PMID: 19047093
顯示更多

收起更多
亞細胞定位：

Cell membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein. Note=Upon LCN2-binding, it is internalized.
蛋白家族：

Major facilitator (TC 2.A.1) superfamily, Organic cation transporter (TC 2.A.1.19) family
組織特異性：

Expressed in brain.
數據庫鏈接：

HGNC: 23095

OMIM: 611461

KEGG: hsa:51310

STRING: 9606.ENSP00000206544

UniGene: Hs.373498

Most popular with customers

YWHAG Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
YWHAB Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF, FC

Species Reactivity: Human, Mouse, Rat
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
XRCC5 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF

Species Reactivity: Human
XPNPEP1 Recombinant Monoclonal Antibody

Applications: ELISA, IHC, FC

Species Reactivity: Human
XDH Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WT1 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WFDC2 Recombinant Monoclonal Antibody

Applications: ELISA, WB, FC

Species Reactivity: Human