PDP1 Antibody, Biotin conjugated

說明書

中文名稱：

PDP1兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA878946LD01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PDP1 Polyclonal antibody
Uniprot No.：

Q9P0J1
基因名：

PDP1
別名：

[Pyruvate dehydrogenase [acetyl transferring]] phosphatase 1; mitochondrial antibody; [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1 antibody; FLJ32517 antibody; Gm1024 antibody; MGC119646 antibody; mitochondrial antibody; PDH antibody; PDP 1 antibody; PDP antibody; Pdp1 antibody; PDP1_HUMAN antibody; PDPC 1 antibody; PDPC antibody; PPM2C antibody; Protein phosphatase 2C antibody; protein phosphatase 2C; magnesium dependent; catalytic subunit antibody; Pyruvate dehydrogenase (Lipoamide) phosphatase phosphatase antibody; Pyruvate dehydrogenase phosphatase catalytic subunit 1 antibody; Pyruvate dehydrogenase phosphatase; catalytic subunit 1 antibody; RP23 203A12.1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial protein (1-154AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex.
基因功能參考文獻：
1. High PDH expression is associated with glucose intolerance. PMID: 28148899
2. YB-1 phosphorylation at Ser-102 is an important prerequisite for CCL5 promoter activation during macrophage differentiation PMID: 24962578
3. the pyruvate dehydrogenase complex is regulated by Tyr phosphorylation of PDP1, which toggles recruitment between ACAT1 and SIRT3 PMID: 24486017
4. Although 7 days of bed rest induced whole body glucose intolerance, exercise-induced PDH regulation in skeletal muscle was not changed, suggesting that exercise-induced PDH regulation in skeletal muscle is maintained in glucose-intolerant individuals. PMID: 21680880
5. catalytic subunit of PDP1 crystals belonged to space group P4(1)2(1)2 or P4(3)2(1)2, with unit-cell parameters a = b = 65.1, c = 216.1 A. PMID: 20208177
6. pyruvate dehydrogenase phosphatase PDP1 is down-regulated in circulating lymphocytes of obese subjects because it is poorly sensitive to magnesium/calcium; this defect is attenuated when plasma insulin is greatly enhanced PMID: 15897476
7. Lower accumulation of free ADP and AMP after the FAT-adapt trial may be responsible for the decreased glycogenolysis and PDH activation during sprinting. PMID: 16188909
8. Functional characterization of the bovine counterpart. PMID: 8396421
9. Functional characterization of the rat counterpart. PMID: 9651365
10. In cultured skin fibroblasts from three patients with congenital lactic acidemia due to a defect in activation of the pyruvate dehydrogenase complex, the PDP-activity was significantly reduced to 50.7%, 64.6% and 63.1% of that of control fibroblasts. PMID: 1327585
11. In postmortem tissue samples, from male child with metabolic acidosis, PDK normally reduced PDH-activity in ATP-presence. Addition of Ca++ and Mg++ did not restored PDH-activity. The defect was attributed to a markedly reduced PDP-activity. PMID: 172850
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相關疾病：

Pyruvate dehydrogenase phosphatase deficiency (PDP deficiency)
亞細胞定位：

Mitochondrion matrix.
蛋白家族：

PP2C family
數據庫鏈接：

HGNC: 9279

OMIM: 605993

KEGG: hsa:54704

STRING: 9606.ENSP00000379503

UniGene: Hs.22265

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